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    Lefty2 left-right determination factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 320202, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lefty2provided by MGI
    Official Full Name
    left-right determination factor 2provided by MGI
    Primary source
    MGI:MGI:2443573
    See related
    Ensembl:ENSMUSG00000066652 AllianceGenome:MGI:2443573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ebaf; Lefta; Leftb; lefty-2; lefty-B; 6030463A22Rik
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in CNS E18 (RPKM 1.4), adrenal adult (RPKM 1.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lefty2 in Genome Data Viewer
    Location:
    1 H4; 1 84.46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180720673..180726672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180893108..180899107)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182805483-182805670 Neighboring gene predicted gene, 18036 Neighboring gene predicted gene, 39714 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182814007-182814116 Neighboring gene STARR-seq mESC enhancer starr_03220 Neighboring gene STARR-positive B cell enhancer ABC_E2592 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182834193-182834494 Neighboring gene pyrroline-5-carboxylate reductase family, member 2 Neighboring gene predicted gene, 32199

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC98569

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    left-right determination factor 2
    Names
    endometrial bleeding associated factor
    left-right determination factor B
    left-right determination, factor A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177099.4NP_796073.1  left-right determination factor 2 preproprotein

      See identical proteins and their annotated locations for NP_796073.1

      Status: REVIEWED

      Source sequence(s)
      AK031621, BE994648
      Consensus CDS
      CCDS15575.1
      UniProtKB/Swiss-Prot
      P57785, Q8BMF7
      UniProtKB/TrEMBL
      A0A0R5T0P8
      Related
      ENSMUSP00000082952.6, ENSMUST00000085797.6
      Conserved Domains (2) summary
      pfam00019
      Location:263355
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:106211
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180720673..180726672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)