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    Tbl1x transducin (beta)-like 1 X-linked [ Mus musculus (house mouse) ]

    Gene ID: 21372, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tbl1xprovided by MGI
    Official Full Name
    transducin (beta)-like 1 X-linkedprovided by MGI
    Primary source
    MGI:MGI:1336172
    See related
    Ensembl:ENSMUSG00000025246 AllianceGenome:MGI:1336172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbl1; 5330429M20
    Summary
    Enables chromatin binding activity; transcription cis-regulatory region binding activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including fat cell differentiation; regulation of DNA-templated transcription; and response to estrogen. Part of transcription regulator complex. Is expressed in cerebral cortex ventricular layer and genitourinary system. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1X (transducin beta like 1 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 17.0), genital fat pad adult (RPKM 14.7) and 28 other tissues See more
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    Genomic context

    See Tbl1x in Genome Data Viewer
    Location:
    X A7.3- B; X 38.31 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (76553053..76706591)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (77509549..77662722)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box-like/WD repeat-containing protein TBL1X
    Names
    transducin beta-like protein 1X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426013.1NP_001412942.1  F-box-like/WD repeat-containing protein TBL1X

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
      Source sequence(s)
      AL671901, AL714017, AL928582
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
    2. NM_001426014.1NP_001412943.1  F-box-like/WD repeat-containing protein TBL1X

      Status: VALIDATED

      Source sequence(s)
      AL671901, AL714017, AL928582
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
    3. NM_001426015.1NP_001412944.1  F-box-like/WD repeat-containing protein TBL1X

      Status: VALIDATED

      Source sequence(s)
      AL671901, AL714017, AL928582
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
    4. NM_001426016.1NP_001412945.1  F-box-like/WD repeat-containing protein TBL1X

      Status: VALIDATED

      Source sequence(s)
      AL671901, AL714017, AL928582
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
    5. NM_001426017.1NP_001412946.1  F-box-like/WD repeat-containing protein TBL1X

      Status: VALIDATED

      Source sequence(s)
      AL671901, AL714017, AL928582
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
    6. NM_020601.3NP_065626.1  F-box-like/WD repeat-containing protein TBL1X

      See identical proteins and their annotated locations for NP_065626.1

      Status: VALIDATED

      Source sequence(s)
      AL671901, AL714017, AL928582
      Consensus CDS
      CCDS41036.1
      UniProtKB/Swiss-Prot
      Q8BMM0, Q8BYQ4, Q8C0A1, Q9QXE7
      Related
      ENSMUSP00000085549.6, ENSMUST00000088217.12
      Conserved Domains (3) summary
      cd00200
      Location:177483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:185232
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:731
      LisH

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      76553053..76706591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)