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    Trim37 tripartite motif-containing 37 [ Mus musculus (house mouse) ]

    Gene ID: 68729, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim37provided by MGI
    Official Full Name
    tripartite motif-containing 37provided by MGI
    Primary source
    MGI:MGI:2153072
    See related
    Ensembl:ENSMUSG00000018548 AllianceGenome:MGI:2153072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUL; TEF3; 1110032A10Rik; 2810004E07Rik
    Summary
    The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in cortex adult (RPKM 34.0), testis adult (RPKM 33.1) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trim37 in Genome Data Viewer
    Location:
    11 C; 11 51.93 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87017675..87141700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87126790..87250874)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKIAA0898

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AK119 ubiquitin ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK119 ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aggresome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aggresome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ESC/E(Z) complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM37
    Names
    RING-type E3 ubiquitin transferase TRIM37
    TRAF encompassing factor 3
    tripartite motif-containing protein 37
    NP_001349954.1
    NP_001349955.1
    NP_001349956.1
    NP_001349957.1
    NP_932104.1
    XP_006534135.1
    XP_011247512.1
    XP_011247514.1
    XP_036012827.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363025.1NP_001349954.1  E3 ubiquitin-protein ligase TRIM37 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596130, AL713917, BX000355
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    2. NM_001363026.1NP_001349955.1  E3 ubiquitin-protein ligase TRIM37 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL596130, AL713917, BX000355
      Conserved Domains (3) summary
      smart00502
      Location:117239
      BBC; B-Box C-terminal domain
      smart00336
      Location:76117
      BBOX; B-Box-type zinc finger
      cd03773
      Location:258391
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    3. NM_001363027.1NP_001349956.1  E3 ubiquitin-protein ligase TRIM37 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL596130, AL713917, BX000355
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    4. NM_001363028.1NP_001349957.1  E3 ubiquitin-protein ligase TRIM37 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL596130, AL713917, BX000355
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    5. NM_197987.2NP_932104.1  E3 ubiquitin-protein ligase TRIM37 isoform 2

      See identical proteins and their annotated locations for NP_932104.1

      Status: REVIEWED

      Source sequence(s)
      AK140822, BC058678, BY457310
      Consensus CDS
      CCDS25210.1
      UniProtKB/Swiss-Prot
      Q5SX31, Q6PCX9, Q8CHC5
      Related
      ENSMUSP00000049057.7, ENSMUST00000041282.13
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87017675..87141700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249212.4XP_011247514.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

      See identical proteins and their annotated locations for XP_011247514.1

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
      cd19779
      Location:93132
      Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    2. XM_006534072.4XP_006534135.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

      See identical proteins and their annotated locations for XP_006534135.1

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
      cd19779
      Location:93132
      Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    3. XM_011249210.3XP_011247512.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

      See identical proteins and their annotated locations for XP_011247512.1

      Conserved Domains (3) summary
      smart00502
      Location:117239
      BBC; B-Box C-terminal domain
      cd03773
      Location:258391
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd19779
      Location:78117
      Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    4. XM_036156934.1XP_036012827.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

      Conserved Domains (3) summary
      smart00502
      Location:117239
      BBC; B-Box C-terminal domain
      cd03773
      Location:258391
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd19779
      Location:78117
      Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins