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    Rab3c RAB3C, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 67295, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab3cprovided by MGI
    Official Full Name
    RAB3C, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1914545
    See related
    Ensembl:ENSMUSG00000021700 AllianceGenome:MGI:1914545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700062I01Rik; 3110015B08Rik; 3110037E15Rik
    Summary
    Enables GTP-dependent protein binding activity. Acts upstream of or within regulation of exocytosis. Located in synaptic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; sensory organ; and skeleton. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 16.0), frontal lobe adult (RPKM 15.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Rab3c in Genome Data Viewer
    Location:
    13 D2.1; 13 61.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (110190721..110417530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (110054187..110280996, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E9403 Neighboring gene STARR-positive B cell enhancer mm9_chr13:110712491-110712792 Neighboring gene STARR-seq mESC enhancer starr_35632 Neighboring gene microRNA 1904 Neighboring gene STARR-seq mESC enhancer starr_35633 Neighboring gene STARR-seq mESC enhancer starr_35634 Neighboring gene predicted gene, 32881 Neighboring gene STARR-seq mESC enhancer starr_35636 Neighboring gene STARR-seq mESC enhancer starr_35637 Neighboring gene predicted gene, 53813 Neighboring gene predicted gene, 41057 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene Grb2-binding adaptor, transmembrane

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124069

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin V binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-3C
    Names
    small GTP-binding protein Rab3C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360099.1NP_001347028.1  ras-related protein Rab-3C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124235, AC154470, CT025643
      Consensus CDS
      CCDS88528.1
      UniProtKB/TrEMBL
      A0A286YDR2, Q3TU26
      Related
      ENSMUSP00000153347.2, ENSMUST00000223922.2
      Conserved Domains (1) summary
      cd01865
      Location:28192
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    2. NM_023852.5NP_076341.1  ras-related protein Rab-3C isoform 1

      See identical proteins and their annotated locations for NP_076341.1

      Status: VALIDATED

      Source sequence(s)
      AK164316, CJ123980, CT025643
      Consensus CDS
      CCDS26764.1
      UniProtKB/Swiss-Prot
      P62823, Q62858, Q62974, Q63482, Q9CXQ1
      UniProtKB/TrEMBL
      Q3TU26, Q542T7
      Related
      ENSMUSP00000132945.2, ENSMUST00000167824.3
      Conserved Domains (1) summary
      cd01865
      Location:30194
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      110190721..110417530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517741.4XP_006517804.1  ras-related protein Rab-3C isoform X1

      UniProtKB/TrEMBL
      Q3TU26
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    2. XM_006517742.5XP_006517805.1  ras-related protein Rab-3C isoform X2

      See identical proteins and their annotated locations for XP_006517805.1

      UniProtKB/TrEMBL
      Q9CXS2
      Related
      ENSMUSP00000153136.2, ENSMUST00000224180.2
      Conserved Domains (1) summary
      cl38936
      Location:30166
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases