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    Prima1 proline rich membrane anchor 1 [ Mus musculus (house mouse) ]

    Gene ID: 170952, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prima1provided by MGI
    Official Full Name
    proline rich membrane anchor 1provided by MGI
    Primary source
    MGI:MGI:1926097
    See related
    Ensembl:ENSMUSG00000041669 AllianceGenome:MGI:1926097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRiMA; B230212M13Rik
    Summary
    Enables enzyme binding activity and protein-membrane adaptor activity. Acts upstream of or within establishment of localization in cell. Located in plasma membrane. Orthologous to human PRIMA1 (proline rich membrane anchor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 7.2), bladder adult (RPKM 4.3) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prima1 in Genome Data Viewer
    Location:
    12 E; 12 52.9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103160712..103208967, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103194453..103242719, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene unc-79 homolog Neighboring gene STARR-seq mESC enhancer starr_33121 Neighboring gene STARR-positive B cell enhancer ABC_E7173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:104569739-104569961 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene family with sequence similarity 181, member A Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 29508 Neighboring gene predicted gene 15523 Neighboring gene ankyrin repeat and SOCS box-containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proline-rich membrane anchor 1
    Names
    acetylcholinesterase membrane anchor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133364.2NP_579942.2  proline-rich membrane anchor 1 precursor

      See identical proteins and their annotated locations for NP_579942.2

      Status: VALIDATED

      Source sequence(s)
      AK039705, AK140034, AY043275
      Consensus CDS
      CCDS26127.1
      UniProtKB/Swiss-Prot
      Q810F0, Q8VHC4
      UniProtKB/TrEMBL
      F8VQJ2
      Related
      ENSMUSP00000074017.4, ENSMUST00000074416.10
      Conserved Domains (1) summary
      pfam16101
      Location:37153
      PRIMA1; Proline-rich membrane anchor 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103160712..103208967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515507.5XP_006515570.1  proline-rich membrane anchor 1 isoform X1

      See identical proteins and their annotated locations for XP_006515570.1

      UniProtKB/Swiss-Prot
      Q810F0, Q8VHC4
      UniProtKB/TrEMBL
      F8VQJ2
      Conserved Domains (1) summary
      pfam16101
      Location:37153
      PRIMA1; Proline-rich membrane anchor 1
    2. XM_006515506.3XP_006515569.1  proline-rich membrane anchor 1 isoform X1

      See identical proteins and their annotated locations for XP_006515569.1

      UniProtKB/Swiss-Prot
      Q810F0, Q8VHC4
      UniProtKB/TrEMBL
      F8VQJ2
      Conserved Domains (1) summary
      pfam16101
      Location:37153
      PRIMA1; Proline-rich membrane anchor 1

    RNA

    1. XR_381482.2 RNA Sequence

    2. XR_381481.2 RNA Sequence

      Related
      ENSMUST00000127843.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178023.2: Suppressed sequence

      Description
      NM_178023.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.