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    Ncapd2 non-SMC condensin I complex, subunit D2 [ Mus musculus (house mouse) ]

    Gene ID: 68298, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ncapd2provided by MGI
    Official Full Name
    non-SMC condensin I complex, subunit D2provided by MGI
    Primary source
    MGI:MGI:1915548
    See related
    Ensembl:ENSMUSG00000038252 AllianceGenome:MGI:1915548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CNAP1; CAP-D2; mKIAA0159; 2810406C15Rik; 2810465G24Rik
    Summary
    Predicted to enable histone binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Located in condensed nuclear chromosome and pronucleus. Part of condensin complex. Is expressed in several structures, including central nervous system; retina outer nuclear layer; and salivary gland. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 53.3), thymus adult (RPKM 40.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncapd2 in Genome Data Viewer
    Location:
    6 F2- F3; 6 59.32 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125144970..125169062, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125168007..125192100, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene STARR-seq mESC enhancer starr_17330 Neighboring gene STARR-positive B cell enhancer ABC_E2207 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene small Cajal body-specific RNA 10 Neighboring gene STARR-seq mESC enhancer starr_17334 Neighboring gene STARR-seq mESC enhancer starr_17335 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene microRNA 3098

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0159, MGC39046

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of condensin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    condensin complex subunit 1
    Names
    XCAP-D2 homolog
    chromosome condensation-related SMC-associated protein 1
    chromosome-associated protein D2
    mCAP-D2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417657.1NP_001404586.1  condensin complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AC166162
      UniProtKB/Swiss-Prot
      Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
      UniProtKB/TrEMBL
      A0A0R4J0H7
    2. NM_146171.2NP_666283.1  condensin complex subunit 1

      See identical proteins and their annotated locations for NP_666283.1

      Status: VALIDATED

      Source sequence(s)
      AC166162
      Consensus CDS
      CCDS39636.1
      UniProtKB/Swiss-Prot
      Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
      UniProtKB/TrEMBL
      A0A0R4J0H7
      Related
      ENSMUSP00000042260.5, ENSMUST00000043848.11
      Conserved Domains (2) summary
      COG5098
      Location:1851235
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:75240
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125144970..125169062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506532.4XP_006506595.1  condensin complex subunit 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
      Conserved Domains (2) summary
      COG5098
      Location:671117
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:1122
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
    2. XM_006506533.4XP_006506596.1  condensin complex subunit 1 isoform X3

      Conserved Domains (2) summary
      COG5098
      Location:185728
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:75240
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    RNA

    1. XR_004933619.1 RNA Sequence