U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [ Mus musculus (house mouse) ]

    Gene ID: 24056, updated on 3-Dec-2024

    Summary

    Official Symbol
    Sh3bp5provided by MGI
    Official Full Name
    SH3-domain binding protein 5 (BTK-associated)provided by MGI
    Primary source
    MGI:MGI:1344391
    See related
    Ensembl:ENSMUSG00000021892 AllianceGenome:MGI:1344391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sab; SH3BP-5
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 46.1), CNS E14 (RPKM 37.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sh3bp5 in Genome Data Viewer
    Location:
    14 19.11 cM; 14 B
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31094571..31158056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31372614..31436100, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SH3 domain-binding protein 5
    Names
    SH3 domain-binding protein that preferentially associates with BTK

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347585.2NP_001334514.1  SH3 domain-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      Consensus CDS
      CCDS84108.1
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
      Related
      ENSMUSP00000098296.4, ENSMUST00000100730.10
    2. NM_001404586.1NP_001391515.1  SH3 domain-binding protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    3. NM_001404587.1NP_001391516.1  SH3 domain-binding protein 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    4. NM_001404588.1NP_001391517.1  SH3 domain-binding protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    5. NM_001404589.1NP_001391518.1  SH3 domain-binding protein 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    6. NM_011894.4NP_036024.2  SH3 domain-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_036024.2

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      Consensus CDS
      CCDS36855.1
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
      Related
      ENSMUSP00000089517.5, ENSMUST00000091903.5
      Conserved Domains (1) summary
      pfam05276
      Location:44270
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31094571..31158056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247814.1XP_030103674.1  SH3 domain-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam05276
      Location:1112
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    2. XM_030247815.1XP_030103675.1  SH3 domain-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam05276
      Location:1112
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)