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    Slco1a1 solute carrier organic anion transporter family, member 1a1 [ Mus musculus (house mouse) ]

    Gene ID: 28248, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slco1a1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1a1provided by MGI
    Primary source
    MGI:MGI:1351891
    See related
    Ensembl:ENSMUSG00000041698 AllianceGenome:MGI:1351891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oatp1; OATP-1; Oatp1a1; Slc21a1; A530084B21
    Summary
    Enables organic anion transmembrane transporter activity. Involved in response to stilbenoid. Acts upstream of or within organic anion transport. Located in basolateral plasma membrane. Is expressed in brain ventricular layer; liver; metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 3.1) and liver E18 (RPKM 0.2) See more
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    Genomic context

    See Slco1a1 in Genome Data Viewer
    Location:
    6 G2; 6 73.09 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141853007..141892688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141907281..141946962, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a4 Neighboring gene predicted gene, 30784 Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene predicted gene, 18159

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within organic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1A1
    Names
    sodium-independent organic anion-transporting polypeptide 1
    solute carrier family 21 (organic anion transporter), member 1
    solute carrier family 21 member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013797.5NP_038825.1  solute carrier organic anion transporter family member 1A1

      See identical proteins and their annotated locations for NP_038825.1

      Status: VALIDATED

      Source sequence(s)
      AC156277, AF223067, BB848260
      Consensus CDS
      CCDS39691.1
      UniProtKB/Swiss-Prot
      Q9QXZ6
      UniProtKB/TrEMBL
      Q53ZW9, Q7TQB3
      Related
      ENSMUSP00000037022.6, ENSMUST00000042119.6
      Conserved Domains (3) summary
      cd06174
      Location:23396
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:436488
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141853007..141892688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)