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    Mal myelin and lymphocyte protein, T cell differentiation protein [ Mus musculus (house mouse) ]

    Gene ID: 17153, updated on 9-Dec-2024

    Summary

    Official Symbol
    Malprovided by MGI
    Official Full Name
    myelin and lymphocyte protein, T cell differentiation proteinprovided by MGI
    Primary source
    MGI:MGI:892970
    See related
    Ensembl:ENSMUSG00000027375 AllianceGenome:MGI:892970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpv17; Vip17
    Summary
    This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Expression
    Biased expression in bladder adult (RPKM 46.2), stomach adult (RPKM 45.2) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mal in Genome Data Viewer
    Location:
    2 F1; 2 62.06 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127475146..127498615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127633226..127656695, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 661 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene STARR-seq mESC enhancer starr_05627 Neighboring gene STARR-seq mESC enhancer starr_05628 Neighboring gene predicted gene, 22889 Neighboring gene poly (A) polymerase alpha pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schmidt-Lanterman incisure IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hinge region between urothelial plaques of apical plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    myelin and lymphocyte protein
    Names
    T-lymphocyte maturation-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171187.1NP_001164658.1  myelin and lymphocyte protein isoform 2

      See identical proteins and their annotated locations for NP_001164658.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK019046, AK158653, BY626921
      Consensus CDS
      CCDS50705.1
      UniProtKB/Swiss-Prot
      O09198
      Related
      ENSMUSP00000028853.7, ENSMUST00000028853.7
    2. NM_010762.5NP_034892.1  myelin and lymphocyte protein isoform 1

      See identical proteins and their annotated locations for NP_034892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158653, BY626921
      Consensus CDS
      CCDS16707.1
      UniProtKB/Swiss-Prot
      O08819, O09109, O09198, Q545Q7, Q9D2R2
      Related
      ENSMUSP00000028854.9, ENSMUST00000028854.15
      Conserved Domains (1) summary
      pfam01284
      Location:19145
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      127475146..127498615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)