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    Rps27a ribosomal protein S27a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps27aprovided by RGD
    Official Full Name
    ribosomal protein S27aprovided by RGD
    Primary source
    RGD:6489478
    See related
    EnsemblRapid:ENSRNOG00000004426 AllianceGenome:RGD:6489478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    The protein encoded by this gene is a fusion protein that contains ubiquitin at its N-terminus and ribosomal protein S27a at its C-terminus. When the human ortholog of this protein is expressed in yeast, it is processed post-translationally into two products, a free ubiquitin monomer and ribosomal protein S27a, a component of the 40S ribosomal subunit. There are multiple pseudogenes of this gene. There is a locus on chromosome 5 (GeneID:81777) that contains an intact copy of the open reading frame of this gene, that is likely to be the result of retrotransposition of an mRNA into the genome. The transcriptional status of this locus cannot be verified at the present time. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Spleen (RPKM 5946.8), Thymus (RPKM 5395.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps27a in Genome Data Viewer
    Location:
    14q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (107486664..107488941, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (103285734..103288011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (113966163..113968440, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene prolyl-tRNA synthetase associated domain containing 1 Neighboring gene mitochondrial translational initiation factor 2 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mass spectrometric analysis of 40 S ribosomal proteins from Rat-1 fibroblasts. Louie DF, et al. J Biol Chem, 1996 Nov 8. PMID 8910435
    2. The carboxyl extensions of two rat ubiquitin fusion proteins are ribosomal proteins S27a and L40. Chan YL, et al. Biochem Biophys Res Commun, 1995 Oct 13. PMID 7488009
    3. Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Yao X, et al. Brain Res, 2007 Nov 28. PMID 17936732
    4. Differential feeding-related regulation of ubiquitin and calbindin9kDa in rat duodenum. Hubbard MJ, et al. Biochim Biophys Acta, 1994 Jul 6. PMID 8031840
    5. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, et al. J Biol Chem, 1977 Dec 25. PMID 925037

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72787

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-ribosomal protein eS31 fusion protein
    Names
    ubiquitin carboxyl extension protein 80
    ubiquitin-40S ribosomal protein S27a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305443.1 → NP_001292372.1  ubiquitin-ribosomal protein eS31 fusion protein

      See identical proteins and their annotated locations for NP_001292372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      FM074661, JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P62982
      UniProtKB/TrEMBL
      A0A8I6G8I7, Q6PED0
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01599
      Location:103 → 147
      Ribosomal_S27; Ribosomal protein S27a

    2. NM_031113.2 → NP_112375.1  ubiquitin-ribosomal protein eS31 fusion protein

      See identical proteins and their annotated locations for NP_112375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      FM074661, JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P62982
      UniProtKB/TrEMBL
      A0A8I6G8I7, Q6PED0
      Related
      ENSRNOP00000005872.1, ENSRNOT00000005872.5
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01599
      Location:103 → 147
      Ribosomal_S27; Ribosomal protein S27a

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      107486664..107488941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62982.2 GenPept UniProtKB/Swiss-Prot:P62982

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