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    Gramd2a GRAM domain containing 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gramd2aprovided by RGD
    Official Full Name
    GRAM domain containing 2Aprovided by RGD
    Primary source
    RGD:1564007
    See related
    EnsemblRapid:ENSRNOG00000025979 AllianceGenome:RGD:1564007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gramd2; RGD1564007
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum membrane and organelle membrane contact site. Orthologous to human GRAMD2A (GRAM domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 68.8) and Heart (RPKM 5.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gramd2a in Genome Data Viewer
    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68975529..69013575)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60079744..60117788)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64503058..64539149)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 6 Neighboring gene U4 spliceosomal RNA Neighboring gene pyruvate kinase M1/2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene myosin IXA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Besprozvannaya M, et al. Elife, 2018 Feb 22. PMID 29469807, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in organelle membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain-containing protein 2A
    Names
    GRAM domain containing 2
    GRAM domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399257.1 → NP_001386186.1  GRAM domain-containing protein 2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Related
      ENSRNOP00000032874.7, ENSRNOT00000036798.8
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      68975529..69013575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243199.5 → XP_006243261.1  GRAM domain-containing protein 2A isoform X4

      See identical proteins and their annotated locations for XP_006243261.1

      UniProtKB/TrEMBL
      D3ZIZ1
      Conserved Domains (1) summary
      cd13220
      Location:84 → 177
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. XM_017596044.3 → XP_017451533.1  GRAM domain-containing protein 2A isoform X3

      Conserved Domains (1) summary
      cd13220
      Location:101 → 194
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    3. XM_017596047.3 → XP_017451536.1  GRAM domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    4. XM_063265141.1 → XP_063121211.1  GRAM domain-containing protein 2A isoform X3

    5. XM_039082424.2 → XP_038938352.1  GRAM domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    6. XM_039082422.2 → XP_038938350.1  GRAM domain-containing protein 2A isoform X2

      Conserved Domains (1) summary
      cd13220
      Location:143 → 236
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    7. XM_006243197.5 → XP_006243259.1  GRAM domain-containing protein 2A isoform X1

      See identical proteins and their annotated locations for XP_006243259.1

      Conserved Domains (1) summary
      cd13220
      Location:143 → 236
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    8. XM_039082426.2 → XP_038938354.1  GRAM domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    9. XM_006243201.5 → XP_006243263.1  GRAM domain-containing protein 2A isoform X5

      See identical proteins and their annotated locations for XP_006243263.1

      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    10. XM_217153.10 → XP_217153.5  GRAM domain-containing protein 2A isoform X5

      See identical proteins and their annotated locations for XP_217153.5

      UniProtKB/TrEMBL
      A0A8I5ZSZ0, A6J534
      Conserved Domains (1) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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