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    Ikbip IKBKB interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ikbipprovided by RGD
    Official Full Name
    IKBKB interacting proteinprovided by RGD
    Primary source
    RGD:1305457
    See related
    EnsemblRapid:ENSRNOG00000008247 AllianceGenome:RGD:1305457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IKIP; RGD1305457
    Summary
    Predicted to be located in endoplasmic reticulum and nucleolus. Orthologous to human IKBIP (IKBKB interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 101.4), Heart (RPKM 84.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ikbip in Genome Data Viewer
    Location:
    7q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27467097..27485776)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25579865..25598548)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31784390..31803200)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B Neighboring gene uncharacterized LOC134479857 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene thymopoietin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Hofer-Warbinek R, et al. Cell Death Differ, 2004 Dec. PMID 15389287
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108928

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase-interacting protein
    Names
    IKK-interacting protein
    i kappa-B kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009430.3 → NP_001009430.2  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001009430.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5EAJ6, Q5M859
      UniProtKB/TrEMBL
      A6IFV0
      Related
      ENSRNOP00000010913.2, ENSRNOT00000010914.6
      Conserved Domains (1) summary
      pfam08702
      Location:113 → 203
      Fib_alpha; Fibrinogen alpha/beta chain family

    2. NM_001412605.1 → NP_001399534.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000010929.3, ENSRNOT00000010929.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      27467097..27485776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EAJ6.1 GenPept UniProtKB/Swiss-Prot:Q5EAJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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