Nudt21 nudix hydrolase 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt21provided by RGD
Official Full Name: nudix hydrolase 21provided by RGD
Primary source: RGD:1305766
See related: EnsemblRapid:ENSRNOG00000042983 AllianceGenome:RGD:1305766
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cpsf5
Summary: Predicted to enable several functions, including histone deacetylase binding activity; mRNA 3'-UTR AU-rich region binding activity; and protein homodimerization activity. Predicted to contribute to RNA binding activity. Predicted to be involved in several processes, including mRNA 3'-end processing; positive regulation of cell differentiation; and protein heterotetramerization. Predicted to be located in centriolar satellite; cytoplasm; and paraspeckles. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human NUDT21 (nudix hydrolase 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 197.0), Brain (RPKM 158.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10980797..10996903)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10974800..10993841)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (11451366..11470637)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these results indicate that endogenous CFIm may promote neuritogenesis in developing neurons by coordinating events upstream of NGF-induced RhoA inactivation.
Title: Knockdown of pre-mRNA cleavage factor Im 25 kDa promotes neurite outgrowth.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to RNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR AU-rich region binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISO Inferred from Sequence Orthology more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA alternative polyadenylation	ISO Inferred from Sequence Orthology more info
involved_in mRNA alternative polyadenylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of pro-B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pro-B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA cleavage factor complex	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage factor complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage factor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in paraspeckles	ISO Inferred from Sequence Orthology more info
located_in paraspeckles	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cleavage and polyadenylation specificity factor subunit 5

Names: cleavage and polyadenylation specific factor 5; nucleoside diphosphate-linked moiety X motif 21; nudix (nucleoside diphosphate linked moiety X)-type motif 21; nudix motif 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.