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    Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r3bprovided by RGD
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', betaprovided by RGD
    Primary source
    RGD:1588134
    See related
    EnsemblRapid:ENSRNOG00000049270 AllianceGenome:RGD:1588134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 53.8), Thymus (RPKM 46.5) and 9 other tissues See more
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    Genomic context

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    See Ppp2r3b in Genome Data Viewer
    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (103496..110739, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (88507..95750, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (1469748..1476353)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 9 like 1 Neighboring gene uncharacterized LOC134481808 Neighboring gene rCG57257-like Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene karyopherin subunit alpha 1, pseudogene 2 Neighboring gene cytokine receptor-like factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Zhang CE, et al. Neurobiol Aging, 2008 Nov. PMID 17537547
    2. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Voorhoeve PM, et al. Oncogene, 1999 Jan 14. PMID 9927208
    3. Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. Nishi A, et al. J Biol Chem, 2017 Jan 27. PMID 27998980, Free PMC Article
    4. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that homocysteine may be an upstream effector to induce AD-like tau hyperphosphorylation through inactivating PP2A.
      Title: Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139492.2 → NP_001132964.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

      See identical proteins and their annotated locations for NP_001132964.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A0V6, B1WBU2
      Related
      ENSRNOP00000065433.2, ENSRNOT00000071648.3
      Conserved Domains (1) summary
      pfam13499
      Location:328 → 422
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      103496..110739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092449.2 → XP_038948377.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0V6
      Conserved Domains (1) summary
      cl41751
      Location:110 → 424
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    2. XM_039092446.2 → XP_038948374.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0V6
      Conserved Domains (1) summary
      cl41751
      Location:132 → 488
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    3. XM_063273623.1 → XP_063129693.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    4. XM_063273624.1 → XP_063129694.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    RNA

    1. XR_010057417.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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