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    Akr1c15 aldo-keto reductase family 1, member C15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1c15provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member C15provided by RGD
    Primary source
    RGD:1307514
    See related
    EnsemblRapid:ENSRNOG00000021735 AllianceGenome:RGD:1307514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RAKc; Akr1cl; Akr1cl1; 17beta-HSD
    Summary
    Enables aldo-keto reductase (NADPH) activity. Predicted to be involved in prostaglandin biosynthetic process and steroid metabolic process. Located in cytoplasm. Orthologous to human AKR1C8 (aldo-keto reductase family 1 member C8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 2564.6), Heart (RPKM 1516.1) and 4 other tissues See more
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    Genomic context

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    See Akr1c15 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71091398..71117985, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66181493..66208090, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69835338..69862093, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C3 Neighboring gene aldo-keto reductase family 1, member C14 Neighboring gene uncharacterized LOC120097737 Neighboring gene urocortin 3 Neighboring gene tubulin, alpha-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues. Endo S, et al. Arch Biochem Biophys, 2007 Sep 1. PMID 17574202
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables farnesol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member C15
    Names
    aldo-keto reductase family 1, member C-like 1
    NP_001103370.1
    XP_038951850.1
    XP_063132700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109900.1 → NP_001103370.1  aldo-keto reductase family 1 member C15

      See identical proteins and their annotated locations for NP_001103370.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/Swiss-Prot
      D3ZF77
      UniProtKB/TrEMBL
      A0A387KC71
      Related
      ENSRNOP00000055113.2, ENSRNOT00000058312.5
      Conserved Domains (1) summary
      COG0656
      Location:9 → 306
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71091398..71117985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095922.2 → XP_038951850.1  aldo-keto reductase family 1 member C15 isoform X2

      Conserved Domains (1) summary
      cl00470
      Location:7 → 191
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    2. XM_063276630.1 → XP_063132700.1  aldo-keto reductase family 1 member C15 isoform X1

    RNA

    1. XR_010058904.1 RNA Sequence

    2. XR_005495305.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZF77.1 GenPept UniProtKB/Swiss-Prot:D3ZF77

    Gene LinkOut

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