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    Akr1c1 aldo-keto reductase family 1, member C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1c1provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member C1provided by RGD
    Primary source
    RGD:1306847
    See related
    EnsemblRapid:ENSRNOG00000038331 AllianceGenome:RGD:1306847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akr1c6; Hsd17b5
    Summary
    Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1618.5) See more
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    Genomic context

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    See Akr1c1 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70720397..70747285, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65810474..65837385, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69441253..69460334, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 3, pseudogene 9 Neighboring gene aldo-keto reductase family 1, member C2 Neighboring gene aldo-keto reductase family 1 member C3-like 1 Neighboring gene aldo-keto reductase family 1, member C12-like 1 Neighboring gene voltage-dependent anion channel 1, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. Ishikura S, et al. J Biochem, 2006 Jun. PMID 16788056
    2. Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. Blouin K, et al. Am J Physiol Endocrinol Metab, 2005 Feb. PMID 15494612
    3. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, et al. J Histochem Cytochem, 2008 Sep. PMID 18574251, Free PMC Article
    4. Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. Deyashiki Y, et al. J Biol Chem, 1995 May 5. PMID 7737980
    5. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Davies NJ, et al. Cancer Res, 2009 Jun 1. PMID 19487289

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC125057

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldo-keto reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase (B-specific) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to jasmonic acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in digestion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to organophosphorus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldo-keto reductase family 1, member C1
    Names
    20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1
    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
    aldo-keto reductase family 1, member C6
    type 5 17beta-hydroxysteroid dehydrogenase
    NP_001028869.1
    XP_006254250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033697.1 → NP_001028869.1  aldo-keto reductase family 1, member C1

      See identical proteins and their annotated locations for NP_001028869.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104716
      UniProtKB/TrEMBL
      Q3MHS3, Q5I0L1
      Related
      ENSRNOP00000055169.2, ENSRNOT00000058367.5
      Conserved Domains (2) summary
      COG0656
      Location:5 → 305
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      70720397..70747285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254188.5 → XP_006254250.1  aldo-keto reductase family 1, member C1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV33
      Conserved Domains (2) summary
      COG0656
      Location:5 → 283
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 282
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

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