Amh anti-Mullerian hormone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amhprovided by RGD
Official Full Name: anti-Mullerian hormoneprovided by RGD
Primary source: RGD:2108
See related: EnsemblRapid:ENSRNOG00000019377 AllianceGenome:RGD:2108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MIS
Summary: Enables transforming growth factor beta receptor binding activity. Involved in several processes, including negative regulation of ovarian follicle development; positive regulation of NF-kappaB transcription factor activity; and preantral ovarian follicle growth. Acts upstream of or within urogenital system development. Located in extracellular space. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 20.2), Muscle (RPKM 8.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9557451..9559867, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8906776..8909192, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11775155..11777503, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat.
Title: Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat.
Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruptiondagger.
Title: Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruption†.
Effects of Ovarian Transplant on Anti-Mullerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
Title: Effects of Ovarian Transplant on Anti-Müllerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
Role of non-classical effects of testosterone and epitestosterone on AMH balance and testicular development parameters.
Title: Role of non-classical effects of testosterone and epitestosterone on AMH balance and testicular development parameters.
The study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females.
Title: Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty.
AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons.
Title: Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.
Resveratrol reduced antimullerian hormone levels in rat model of polycystic ovary syndrome.
Title: Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome.
AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly.
Title: Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly.
In ovaries from adult cycling rats AMH protein is localized in large primary and secondary follicles and not in primordial or small primary follicles, with its highest expression in the largest preantral follicles.
Title: Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.
Mullerian inhibiting substance regulates gonadotropin gene expression
Title: Regulation of gonadotropin gene expression by Mullerian inhibiting substance.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

PMC203309P1 (e-PCR)
- UniSTS:271898

NoName (e-PCR)
- UniSTS:547550

Amh (e-PCR), detects polymorphism
- UniSTS:547550

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Leydig cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Leydig cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in Mullerian duct regression	IBA Inferred from Biological aspect of Ancestor more info
involved_in Mullerian duct regression	ISO Inferred from Sequence Orthology more info
involved_in Mullerian duct regression	ISS Inferred from Sequence or Structural Similarity more info
involved_in Mullerian duct regression	TAS Traceable Author Statement more info	PubMed
involved_in anti-Mullerian hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in anti-Mullerian hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ovarian follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in preantral ovarian follicle growth	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sex determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urogenital system development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: muellerian-inhibiting factor

Names: Anti - Mullerian hormone (Mulerian inhibiting substance); anti-Muellerian hormone; muellerian-inhibiting substance

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012902.2 → NP_037034.1 muellerian-inhibiting factor precursor

See identical proteins and their annotated locations for NP_037034.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P49000

UniProtKB/TrEMBL

A6K8G0

Related

ENSRNOP00000026220.1, ENSRNOT00000026220.4

Conserved Domains (2) summary

smart00204
Location:455 → 553

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam04709
Location:74 → 417

AMH_N; Anti-Mullerian hormone, N terminal region