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    Nmrk1 nicotinamide riboside kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmrk1provided by RGD
    Official Full Name
    nicotinamide riboside kinase 1provided by RGD
    Primary source
    RGD:1564687
    See related
    EnsemblRapid:ENSRNOG00000012665 AllianceGenome:RGD:1564687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nrk1
    Summary
    Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to be involved in NAD biosynthetic process and phosphorylation. Predicted to be active in cytoplasm. Orthologous to human NMRK1 (nicotinamide riboside kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 80.4), Adrenal (RPKM 33.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmrk1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (225475975..225503414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (216049350..216076792)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (234721992..234749452, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein with serine rich domain 1, pseudogene 3 Neighboring gene osteoclast stimulating factor 1 Neighboring gene ribosomal protein S15, pseudogene 7 Neighboring gene uncharacterized LOC134485209 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene similar to human chromosome 9 open reading frame 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, et al. Cell, 2004 May 14. PMID 15137942
    2. Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, et al. PLoS Biol, 2007 Oct 2. PMID 17914902, Free PMC Article
    3. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, et al. Endocr Rev, 2010 Apr. PMID 20007326, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate riboside kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylnicotinamide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosylnicotinate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide riboside kinase 1
    Names
    RNK 1
    nicotinic acid riboside kinase 1
    nmR-K 1
    ribosylnicotinamide kinase 1
    ribosylnicotinic acid kinase 1
    NP_001019463.1
    XP_008758512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024292.1 → NP_001019463.1  nicotinamide riboside kinase 1

      See identical proteins and their annotated locations for NP_001019463.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079144
      UniProtKB/Swiss-Prot
      Q6AY91
      UniProtKB/TrEMBL
      A0A8I6ASX6, A6I0K2
      Related
      ENSRNOP00000110044.1, ENSRNOT00000157032.1
      Conserved Domains (1) summary
      cd02024
      Location:5 → 158
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      225475975..225503414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760290.4 → XP_008758512.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASX6
      Related
      ENSRNOP00000091828.2, ENSRNOT00000117378.2
      Conserved Domains (1) summary
      cd02024
      Location:5 → 158
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY91.1 GenPept UniProtKB/Swiss-Prot:Q6AY91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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