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    Nktr natural killer cell triggering receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100364165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nktrprovided by RGD
    Official Full Name
    natural killer cell triggering receptorprovided by RGD
    Primary source
    RGD:2321593
    See related
    EnsemblRapid:ENSRNOG00000049128 AllianceGenome:RGD:2321593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in membrane. Predicted to be active in mitochondrion and nucleus. Orthologous to human NKTR (natural killer cell triggering receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 215.0), Thymus (RPKM 213.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nktr in Genome Data Viewer
    Location:
    8q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130255541..130298001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121380010..121420495)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130357464..130395425)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene SS18 like 2 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like family member 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NK-tumor recognition protein
    Names
    natural killer tumor recognition sequence-like
    natural killer-tumor recognition sequence
    NP_001414339.1
    XP_038938667.1
    XP_038938669.1
    XP_038938673.1
    XP_038938674.1
    XP_038938678.1
    XP_063120781.1
    XP_063120782.1
    XP_063120783.1
    XP_063120784.1
    XP_063120785.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427410.1 → NP_001414339.1  NK-tumor recognition protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GB94
      Related
      ENSRNOP00000097585.2, ENSRNOT00000107845.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130255541..130298001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264715.1 → XP_063120785.1  NK-tumor recognition protein isoform X7

    2. XM_039082750.2 → XP_038938678.1  NK-tumor recognition protein isoform X8

      Conserved Domains (1) summary
      cl00197
      Location:66 → 156
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    3. XM_063264714.1 → XP_063120784.1  NK-tumor recognition protein isoform X6

    4. XM_039082739.2 → XP_038938667.1  NK-tumor recognition protein isoform X1

      UniProtKB/TrEMBL
      M0R991
      Related
      ENSRNOP00000087797.2, ENSRNOT00000106585.2
      Conserved Domains (1) summary
      cl00197
      Location:66 → 233
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    5. XM_039082741.2 → XP_038938669.1  NK-tumor recognition protein isoform X2

      UniProtKB/TrEMBL
      M0R991
      Conserved Domains (1) summary
      cl00197
      Location:66 → 233
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    6. XM_063264711.1 → XP_063120781.1  NK-tumor recognition protein isoform X4

      UniProtKB/TrEMBL
      M0R991

    7. XM_063264712.1 → XP_063120782.1  NK-tumor recognition protein isoform X4

      UniProtKB/TrEMBL
      M0R991

    8. XM_039082746.2 → XP_038938674.1  NK-tumor recognition protein isoform X3

      UniProtKB/TrEMBL
      M0R991
      Conserved Domains (1) summary
      cl00197
      Location:1 → 62
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    9. XM_039082745.2 → XP_038938673.1  NK-tumor recognition protein isoform X3

      UniProtKB/TrEMBL
      M0R991
      Related
      ENSRNOP00000066054.4, ENSRNOT00000071152.4
      Conserved Domains (1) summary
      cl00197
      Location:1 → 62
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    10. XM_063264713.1 → XP_063120783.1  NK-tumor recognition protein isoform X5

      UniProtKB/TrEMBL
      A6I455

    RNA

    1. XR_005488595.2 RNA Sequence

    2. XR_005488594.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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