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    Kcng2 potassium voltage-gated channel modifier subfamily G member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcng2provided by RGD
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 2provided by RGD
    Primary source
    RGD:1309521
    See related
    EnsemblRapid:ENSRNOG00000053640 AllianceGenome:RGD:1309521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv6.2
    Summary
    Enables potassium channel regulator activity. Involved in regulation of potassium ion transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG2 (potassium voltage-gated channel modifier subfamily G member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 213.8), Adrenal (RPKM 29.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcng2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (76017225..76085377, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73742224..73810420, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76808294..76880742, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2 Neighboring gene uncharacterized LOC120098179 Neighboring gene uncharacterized LOC134482964 Neighboring gene uncharacterized LOC103694249 Neighboring gene CTD phosphatase subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. Zhu XR, et al. Recept Channels, 1999. PMID 10551266
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG2; potassium voltage-gated channel subfamily G member 2
    Names
    cardiac potassium channel subunit (Kv6.2)
    potassium channel, voltage gated modifier subfamily G, member 2
    potassium voltage-gated channel, subfamily G, member 2
    voltage-gated potassium channel subunit Kv6.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107372.1 → NP_001100842.1  voltage-gated potassium channel regulatory subunit KCNG2

      See identical proteins and their annotated locations for NP_001100842.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474021
      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Related
      ENSRNOP00000069556.1, ENSRNOT00000088054.3
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      76017225..76085377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096771.2 → XP_038952699.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    2. XM_006254947.4 → XP_006255009.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      See identical proteins and their annotated locations for XP_006255009.1

      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    3. XM_017600944.3 → XP_017456433.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    4. XM_006254948.5 → XP_006255010.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      See identical proteins and their annotated locations for XP_006255010.1

      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    5. XM_008772136.4 → XP_008770358.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      See identical proteins and their annotated locations for XP_008770358.1

      UniProtKB/Swiss-Prot
      Q9QYU3
      UniProtKB/TrEMBL
      A6K5H5
      Conserved Domains (2) summary
      cd18382
      Location:33 → 127
      BTB_POZ_Kv6_KCNG; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYU3.1 GenPept UniProtKB/Swiss-Prot:Q9QYU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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