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    Rchy1 ring finger and CHY zinc finger domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rchy1provided by RGD
    Official Full Name
    ring finger and CHY zinc finger domain containing 1provided by RGD
    Primary source
    RGD:1359180
    See related
    EnsemblRapid:ENSRNOG00000002546 AllianceGenome:RGD:1359180
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pirh2
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of protein metabolic process; protein autoubiquitination; and rescue of stalled ribosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Biomarker of sciatic neuropathy. Orthologous to human RCHY1 (ring finger and CHY zinc finger domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 225.7), Muscle (RPKM 224.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rchy1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16397533..16413286)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (16113263..16129017)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17615968..17631715)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene cyclin dependent kinase like 2 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene THAP domain containing 6 Neighboring gene uncharacterized LOC102546535 Neighboring gene uncharacterized LOC134481723 Neighboring gene uncharacterized LOC134481724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pirh2 modulates the mitochondrial function and cytochrome c-mediated neuronal death during Alzheimer's disease. Singh A, et al. Cell Death Dis, 2024 May 13. PMID 38740775, Free PMC Article
    2. Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin. Escarcega RD, et al. J Biol Chem, 2023 Oct. PMID 37579947, Free PMC Article
    3. Human Pirh2 is a novel inhibitor of prototype foamy virus replication. Dong L, et al. Viruses, 2015 Apr 2. PMID 25848801, Free PMC Article
    4. Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats. Wu X, et al. J Mol Neurosci, 2012 Jan. PMID 21728064
    5. Dynamic changes of PIRH2 and p27kip1 expression in injured rat sciatic nerve. Li H, et al. Neurol Sci, 2012 Aug. PMID 21959983

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pirh2 modulates the mitochondrial function and cytochrome c-mediated neuronal death during Alzheimer's disease.
      Title: Pirh2 modulates the mitochondrial function and cytochrome c-mediated neuronal death during Alzheimer's disease.
    2. Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin.
      Title: Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin.
    3. Pirh2 may be a negative regulator of p27(kip1) and associated with glial proliferation.
      Title: Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94651

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger and CHY zinc finger domain-containing protein 1
    Names
    ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
    NP_001007619.1
    XP_038947603.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007618.1 → NP_001007619.1  RING finger and CHY zinc finger domain-containing protein 1

      See identical proteins and their annotated locations for NP_001007619.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083739
      UniProtKB/TrEMBL
      A0A8I5ZWY8, A6KKB6, A6KKB7, F7F3N3, Q5XIE4
      Related
      ENSRNOP00000003470.3, ENSRNOT00000003470.6
      Conserved Domains (3) summary
      pfam05495
      Location:20 → 93
      zf-CHY; CHY zinc finger
      pfam13639
      Location:144 → 186
      zf-RING_2; Ring finger domain
      pfam14599
      Location:191 → 249
      zinc_ribbon_6; Zinc-ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16397533..16413286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091675.1 → XP_038947603.1  RING finger and CHY zinc finger domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KKC0
      Conserved Domains (2) summary
      cd16464
      Location:17 → 60
      RING-H2_Pirh2; RING finger, H2 subclass, found in p53-induced RING-H2 protein (Pirh2) and similar proteins
      pfam14599
      Location:64 → 122
      zinc_ribbon_6; Zinc-ribbon
    Nucleotide Protein Strain
    Heading Accession and Version

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