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    Fut8 fucosyltransferase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 432392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fut8provided by RGD
    Official Full Name
    fucosyltransferase 8provided by RGD
    Primary source
    RGD:1303096
    See related
    EnsemblRapid:ENSRNOG00000008451 AllianceGenome:RGD:1303096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycoprotein 6-alpha-L-fucosyltransferase activity. Predicted to be involved in GDP-L-fucose metabolic process; N-glycan fucosylation; and protein N-linked glycosylation via asparagine. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; fibroblast migration; and regulation of cellular response to oxidative stress. Predicted to be located in Golgi cisterna membrane. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 118.8), Kidney (RPKM 102.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fut8 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101682354..101909784)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95949246..96176677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (100305957..100537208)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479401 Neighboring gene small nucleolar RNA, H/ACA box 50D Neighboring gene ankyrin repeat domain-containing protein 49-like Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120103557

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0. Teylaert B, et al. BMC Biotechnol, 2011 Jan 5. PMID 21208406, Free PMC Article
    2. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. Ihara H, et al. Glycobiology, 2007 May. PMID 17172260
    3. Molecular cloning of mouse alpha-1,6-fucosyltransferase and expression of its mRNA in the developing cerebrum. Hayashi H, et al. DNA Seq, 2000. PMID 10902914
    4. Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions. Zhao Y, et al. J Biol Chem, 2006 Dec 15. PMID 17043354
    5. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cDNAs encoding the rat alpha1,6-fucosyltransferase (FucT VIII) were cloned from YB2/0 cells by polymerase chain reaction-based and 5' RNA-Ligase-Mediated RACE methods.
      Title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-(1->6)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->6)-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycoprotein 6-alpha-L-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycoprotein 6-alpha-L-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycoprotein 6-alpha-L-fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-L-fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-L-fucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-L-fucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in N-glycan fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within N-glycan fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within receptor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,6)-fucosyltransferase
    Names
    GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
    GDP-fucose--glycoprotein fucosyltransferase
    alpha1-6FucT
    fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
    glycoprotein 6-alpha-L-fucosyltransferase
    NP_001002289.2
    NP_001399118.1
    XP_038968588.1
    XP_063118317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002289.2 → NP_001002289.2  alpha-(1,6)-fucosyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q6EV76
      UniProtKB/TrEMBL
      A6HCC9, D4IGX4, D4IGX5

    2. NM_001412189.1 → NP_001399118.1  alpha-(1,6)-fucosyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q6EV76
      UniProtKB/TrEMBL
      A6HCC9, D4IGX4, D4IGX5
      Related
      ENSRNOP00000011220.2, ENSRNOT00000011220.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      101682354..101909784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112660.2 → XP_038968588.1  alpha-(1,6)-fucosyltransferase isoform X2

      UniProtKB/Swiss-Prot
      Q6EV76
      Conserved Domains (2) summary
      cd11300
      Location:208 → 533
      Fut8_like; Alpha 1-6-fucosyltransferase
      cd11792
      Location:540 → 594
      SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

    2. XM_063262247.1 → XP_063118317.1  alpha-(1,6)-fucosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q6EV76
      UniProtKB/TrEMBL
      A6HCC9, D4IGX4, D4IGX5
      Related
      ENSRNOP00000089026.1, ENSRNOT00000096219.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6EV76.1 GenPept UniProtKB/Swiss-Prot:Q6EV76

    Gene LinkOut

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