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    Hbe1 hemoglobin subunit epsilon 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hbe1provided by RGD
    Official Full Name
    hemoglobin subunit epsilon 1provided by RGD
    Primary source
    RGD:1305115
    See related
    EnsemblRapid:ENSRNOG00000029286 AllianceGenome:RGD:1305115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glnb1; Hbb-y
    Summary
    Enables hemoglobin alpha binding activity. Involved in response to organic cyclic compound. Part of hemoglobin complex. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.8) and Testes (RPKM 13.2) See more
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    Genomic context

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    See Hbe1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (167694820..167872091, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158282931..158458855, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (169003904..169005184, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hemoglobin subunit gamma 1 Neighboring gene hemoglobin, epsilon 2 Neighboring gene olfactory receptor family 51 subfamily B member 4B Neighboring gene olfactory receptor family 51 subfamily B member 4 Neighboring gene olfactory receptor family 51 subfamily B member 17 Neighboring gene olfactory receptor family 51 subfamily B member 6 Neighboring gene olfactory receptor family 51 subfamily M member 1, pseudogene 1 Neighboring gene olfactory receptor pseudogene 134 Neighboring gene olfactory receptor family 51 subfamily K member 2 Neighboring gene olfactory receptor family 51 subfamily K member 7 Neighboring gene transmembrane p24 trafficking protein 5, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily K member 1B, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1D Neighboring gene uncharacterized LOC134484818 Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene sorting nexin 12, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1E Neighboring gene olfactory receptor family 51 subfamily K member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. Green NS, et al. PLoS One, 2013. PMID 23409025, Free PMC Article
    2. Gene expression profiling of androgen receptor antagonists in the rat fetal testis reveals few common gene targets. Mu X, et al. J Biochem Mol Toxicol, 2006. PMID 16498641
    3. A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease. He Z, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12124399, Free PMC Article
    4. Identification of five embryonic hemoglobins of rat and ontogeny of their constituent globins during fetal development. Iwahara SI, et al. J Biochem, 1996 Feb. PMID 8882731
    5. Molecular cloning and characterization of two sets of alpha-theta genes in the rat alpha-like globin gene cluster. Satoh H, et al. Gene, 1999 Apr 1. PMID 10196478

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to haptoglobin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hemoglobin alpha binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hemoglobin alpha binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of haptoglobin-hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin subunit epsilon 1
    Names
    epsilon 1 globin
    globin b1
    hemoglobin Y, beta-like embryonic chain
    hemoglobin, epsilon 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008890.2 → NP_001008890.1  hemoglobin subunit epsilon 1

      See identical proteins and their annotated locations for NP_001008890.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A1K0GY47, O88752
      Related
      ENSRNOP00000040010.2, ENSRNOT00000043719.6
      Conserved Domains (1) summary
      cd08925
      Location:7 → 146
      Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      167694820..167872091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106648.2 → XP_038962576.1  hemoglobin subunit epsilon 1 isoform X1

      Conserved Domains (1) summary
      cd08925
      Location:8 → 123
      Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    2. XM_039106650.2 → XP_038962578.1  hemoglobin subunit epsilon 1 isoform X1

      Conserved Domains (1) summary
      cd08925
      Location:8 → 123
      Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    3. XM_063285351.1 → XP_063141421.1  hemoglobin subunit epsilon 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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