Fmo1 flavin containing dimethylaniline monoxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmo1provided by RGD
Official Full Name: flavin containing dimethylaniline monoxygenase 1provided by RGD
Primary source: RGD:2622
See related: EnsemblRapid:ENSRNOG00000034191 AllianceGenome:RGD:2622
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RFMO1A
Summary: Enables N,N-dimethylaniline monooxygenase activity and trimethylamine monooxygenase activity. Involved in response to lipopolysaccharide. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1119.2), Lung (RPKM 550.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (77715405..77747666, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (75182184..75214439, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (80712885..80745095, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FMO, whose dysfunction could be a reason for the apoptosis of dopaminergic neurons in rotenone model, might be a new clue of pathological proteins in rotenone model of parkinsonism
Title: Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism.
Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
results suggest that nitric oxide acts directly in a cyclic GMP-independent mechanism by decreasing the half-life of flavin-containing monooxygenase 1 (FMO1) mRNA, thereby inducing impairment of FMO-related functions in endotoxemia
Title: Hepatic flavin-containing monooxygenase activity attenuated by cGMP-independent nitric oxide-mediated mRNA destabilization.
the relationship between gender and development in the expression of FMO1 in the liver and kidney was determined
Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N,N-dimethylaniline monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables N,N-dimethylaniline monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables hypotaurine monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables hypotaurine monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables trimethylamine monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in taurine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in taurine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in toxin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: flavin-containing monooxygenase 1

Names: FMO 1; Flavin-containing monooxygenase 1; dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; hepatic flavin-containing monooxygenase 1; trimethylamine monooxygenase

NP_036924.1

EC 1.14.13.148

EC 1.14.13.8

XP_006250207.1

EC 1.14.13.148

EC 1.14.13.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012792.1 → NP_036924.1 flavin-containing monooxygenase 1

See identical proteins and their annotated locations for NP_036924.1

Status: PROVISIONAL

Source sequence(s)

M84719

UniProtKB/TrEMBL

A0A8L2R702

Related

ENSRNOP00000044613.1, ENSRNOT00000041908.5

Conserved Domains (2) summary

pfam00743
Location:3 → 532

FMO-like; Flavin-binding monooxygenase-like

cl21454
Location:81 → 342

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

77715405..77747666 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250145.5 → XP_006250207.1 flavin-containing monooxygenase 1 isoform X1

See identical proteins and their annotated locations for XP_006250207.1

UniProtKB/Swiss-Prot

P36365, Q6P7Q5

UniProtKB/TrEMBL

A0A8L2R702, A6IDA3

Conserved Domains (2) summary

pfam00743
Location:3 → 532

FMO-like; Flavin-binding monooxygenase-like

cl21454
Location:81 → 342

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins