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    Rsph3 radial spoke head 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsph3provided by RGD
    Official Full Name
    radial spoke head 3provided by RGD
    Primary source
    RGD:1311306
    See related
    EnsemblRapid:ENSRNOG00000018762 AllianceGenome:RGD:1311306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rshl2
    Summary
    Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 32. Orthologous to human RSPH3 (radial spoke head 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 34.9), Lung (RPKM 13.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rsph3 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49506988..49565740, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47101961..47155201, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47412151..47478924, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ezrin Neighboring gene RNA, U6 small nuclear 546 Neighboring gene uncharacterized LOC120099118 Neighboring gene T-cell activation RhoGTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization. Jeanson L, et al. Hum Mutat, 2016 Aug. PMID 27120127
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 3 homolog
    Names
    radial spoke 3 homolog
    radial spoke head 3 homolog
    radial spokehead-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108463.3 → NP_001101933.2  radial spoke head protein 3 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LRY1
      Related
      ENSRNOP00000103404.1, ENSRNOT00000160516.1
      Conserved Domains (1) summary
      pfam06098
      Location:189 → 468
      Radial_spoke_3; Radial spoke protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49506988..49565740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227910.5 → XP_006227972.1  radial spoke head protein 3 homolog isoform X2

      See identical proteins and their annotated locations for XP_006227972.1

      UniProtKB/TrEMBL
      F1LRY1
      Related
      ENSRNOP00000063027.4, ENSRNOT00000067916.5
      Conserved Domains (1) summary
      pfam06098
      Location:189 → 468
      Radial_spoke_3; Radial spoke protein 3

    2. XM_006227909.5 → XP_006227971.1  radial spoke head protein 3 homolog isoform X1

      See identical proteins and their annotated locations for XP_006227971.1

      UniProtKB/TrEMBL
      F1LRY1
      Conserved Domains (1) summary
      pfam06098
      Location:189 → 468
      Radial_spoke_3; Radial spoke protein 3

    3. XM_008758741.4 → XP_008756963.1  radial spoke head protein 3 homolog isoform X1

      See identical proteins and their annotated locations for XP_008756963.1

      UniProtKB/TrEMBL
      F1LRY1
      Conserved Domains (1) summary
      pfam06098
      Location:189 → 468
      Radial_spoke_3; Radial spoke protein 3

    4. XM_039081299.2 → XP_038937227.1  radial spoke head protein 3 homolog isoform X4

      UniProtKB/TrEMBL
      B5DFN5
      Conserved Domains (1) summary
      pfam06098
      Location:1 → 196
      Radial_spoke_3; Radial spoke protein 3

    5. XM_039081295.2 → XP_038937223.1  radial spoke head protein 3 homolog isoform X4

      UniProtKB/TrEMBL
      B5DFN5
      Conserved Domains (1) summary
      pfam06098
      Location:1 → 196
      Radial_spoke_3; Radial spoke protein 3

    6. XM_063266140.1 → XP_063122210.1  radial spoke head protein 3 homolog isoform X3

      UniProtKB/TrEMBL
      A6JKU3
    Nucleotide Protein Strain
    Heading Accession and Version

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