Mturn maturin, neural progenitor differentiation regulator homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mturnprovided by RGD
Official Full Name: maturin, neural progenitor differentiation regulator homologprovided by RGD
Primary source: RGD:1549700
See related: EnsemblRapid:ENSRNOG00000010205 AllianceGenome:RGD:1549700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of MAPK cascade; and positive regulation of megakaryocyte differentiation. Predicted to be active in cytoplasm. Orthologous to human MTURN (maturin, neural progenitor differentiation regulator homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 195.4), Adrenal (RPKM 96.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85137825..85158790)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (83807528..83828494)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (84854341..84875300)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of megakaryocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: maturin

Names: UPF0452 protein C7orf41 homolog; maturin neural progenitor differentiation regulator protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007645.2 → NP_001007646.1 maturin

See identical proteins and their annotated locations for NP_001007646.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q5XI20

Related

ENSRNOP00000105309.1, ENSRNOT00000124611.1

Conserved Domains (1) summary

pfam15167
Location:4 → 131

DUF4581; Domain of unknown function (DUF4581)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

85137825..85158790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762880.4 → XP_008761102.1 maturin isoform X1

UniProtKB/TrEMBL

A0A8I6ARQ2

Related

ENSRNOP00000096014.1, ENSRNOT00000107913.2

Conserved Domains (1) summary

pfam15167
Location:4 → 129

DUF4581; Domain of unknown function (DUF4581)