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    Pheta1 PH domain containing endocytic trafficking adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pheta1provided by RGD
    Official Full Name
    PH domain containing endocytic trafficking adaptor 1provided by RGD
    Primary source
    RGD:1310656
    See related
    EnsemblRapid:ENSRNOG00000028206 AllianceGenome:RGD:1310656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ses1; Fam109a; IPIP27A; RGD1310656
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in clathrin-coated vesicle. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Orthologous to human PHETA1 (PH domain containing endocytic trafficking adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 52.1), Brain (RPKM 38.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pheta1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40372553..40378321, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34711831..34717601, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40225316..40230573, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC120095978 Neighboring gene uncharacterized LOC134481298 Neighboring gene SH2B adaptor protein 3 Neighboring gene ataxin 2 Neighboring gene F-box protein 22, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway. Noakes CJ, et al. Mol Biol Cell, 2011 Mar 1. PMID 21233288, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sesquipedalian-1
    Names
    27 kDa inositol polyphosphate phosphatase interacting protein A
    family with sequence similarity 109, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376816.1 → NP_001363745.1  sesquipedalian-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000110619.1, ENSRNOT00000143153.1
      Conserved Domains (1) summary
      cd13288
      Location:11 → 130
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40372553..40378321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089245.2 → XP_038945173.1  sesquipedalian-1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000034778.3, ENSRNOT00000030600.5
      Conserved Domains (1) summary
      cd13288
      Location:11 → 130
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain

    2. XM_039089243.2 → XP_038945171.1  sesquipedalian-1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000109634.1, ENSRNOT00000131060.1
      Conserved Domains (1) summary
      cd13288
      Location:11 → 130
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain

    3. XM_063271210.1 → XP_063127280.1  sesquipedalian-1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000086694.1, ENSRNOT00000098471.2

    4. XM_039089241.2 → XP_038945169.1  sesquipedalian-1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000105742.1, ENSRNOT00000166680.1
      Conserved Domains (1) summary
      cd13288
      Location:11 → 130
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain

    5. XM_039089242.2 → XP_038945170.1  sesquipedalian-1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZL52
      Related
      ENSRNOP00000085047.1, ENSRNOT00000108435.2
      Conserved Domains (1) summary
      cd13288
      Location:11 → 130
      PH_Ses; Sesquipedalian family Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZL52.1 GenPept UniProtKB/Swiss-Prot:D3ZL52

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