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    Bub1 BUB1 mitotic checkpoint serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bub1provided by RGD
    Official Full Name
    BUB1 mitotic checkpoint serine/threonine kinaseprovided by RGD
    Primary source
    RGD:1311707
    See related
    EnsemblRapid:ENSRNOG00000032778 AllianceGenome:RGD:1311707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone H2A kinase activity and protein serine/threonine kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric; mitotic spindle assembly checkpoint signaling; and positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Predicted to act upstream of or within chromosome segregation and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in condensed chromosome, centromeric region; cytosol; and nucleoplasm. Predicted to be part of outer kinetochore. Predicted to be active in kinetochore and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 245.8), Testes (RPKM 134.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bub1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (135473525..135504921, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (115020254..115051650, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (120373604..120404910, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nephrocystin 1 Neighboring gene WW domain containing adaptor with coiled-coil, pseudogene 2 Neighboring gene mitoregulin Neighboring gene acyl-CoA oxidase-like Neighboring gene Bcl2-like 11 Neighboring gene small nuclear ribonucleoprotein polypeptide F, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. Johnson VL, et al. J Cell Sci, 2004 Mar 15. PMID 15020684
    2. Bub1 regulates chromosome segregation in a kinetochore-independent manner. Klebig C, et al. J Cell Biol, 2009 Jun 1. PMID 19487456, Free PMC Article
    3. Mutations of mitotic checkpoint genes in human cancers. Cahill DP, et al. Nature, 1998 Mar 19. PMID 9521327
    4. Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Kitajima TS, et al. Curr Biol, 2005 Feb 22. PMID 15723797
    5. Mammalian BUB1 protein kinases: map positions and in vivo expression. Pangilinan F, et al. Genomics, 1997 Dec 15. PMID 9441741

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2A kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitotic checkpoint serine/threonine-protein kinase BUB1
    Names
    budding uninhibited by benzimidazoles 1 homolog
    NP_001099977.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106507.1 → NP_001099977.1  mitotic checkpoint serine/threonine-protein kinase BUB1

      See identical proteins and their annotated locations for NP_001099977.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6GIT9, A6HQ28, D4A5D3
      Related
      ENSRNOP00000042114.3, ENSRNOT00000051783.6
      Conserved Domains (2) summary
      pfam08311
      Location:6 → 125
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:764 → 1047
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      135473525..135504921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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