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    Cldn18 claudin 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cldn18provided by RGD
    Official Full Name
    claudin 18provided by RGD
    Primary source
    RGD:1359696
    See related
    EnsemblRapid:ENSRNOG00000030386 AllianceGenome:RGD:1359696
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable structural molecule activity. Involved in response to ethanol. Predicted to be located in tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN18 (claudin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1068.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cldn18 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (109125819..109145110, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100246499..100265797, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107933725..107960656, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547387 Neighboring gene DAZ interacting zinc finger protein 1-like Neighboring gene uncharacterized LOC134480090 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480091

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Fernandez AL, et al. Alcohol, 2007 Aug. PMID 17889313, Free PMC Article
    2. Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. Linares GR, et al. J Bone Miner Res, 2012 Jul. PMID 22437732, Free PMC Article
    3. Structure and function of claudins. Krause G, et al. Biochim Biophys Acta, 2008 Mar. PMID 18036336
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial fluid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoclast development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tight junction organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    claudin-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014096.1 → NP_001014118.1  claudin-18 precursor

      See identical proteins and their annotated locations for NP_001014118.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088427
      UniProtKB/Swiss-Prot
      A0A8I6A5Z5, F1LNR6, Q5I0E5
      Related
      ENSRNOP00000046247.4, ENSRNOT00000052043.6
      Conserved Domains (1) summary
      cl21598
      Location:43 → 191
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      109125819..109145110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081548.2 → XP_038937476.1  claudin-18 isoform X1

      Conserved Domains (1) summary
      cl21598
      Location:13 → 128
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0E5.1 GenPept UniProtKB/Swiss-Prot:Q5I0E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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