Nlrx1 NLR family member X1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrx1provided by RGD
Official Full Name: NLR family member X1provided by RGD
Primary source: RGD:1311293
See related: EnsemblRapid:ENSRNOG00000052386 AllianceGenome:RGD:1311293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311293
Summary: Predicted to enable ATP binding activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of cytokine production and regulation of defense response. Predicted to be located in plasma membrane. Predicted to be active in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 80.1), Kidney (RPKM 60.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53486866..53503498, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44588476..44606678, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48583559..48600203, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
Title: Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation.
Title: Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation.
Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
Title: Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NLR family member X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025010.1 → NP_001020181.1 NLR family member X1 precursor

See identical proteins and their annotated locations for NP_001020181.1

Status: PROVISIONAL

Source sequence(s)

BC089834

UniProtKB/Swiss-Prot

Q5FVQ8

UniProtKB/TrEMBL

A6J3W5

Related

ENSRNOP00000071934.2, ENSRNOT00000077958.3

Conserved Domains (3) summary

sd00033
Location:696 → 724

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:696 → 901

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:159 → 318

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

53486866..53503498 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081422.2 → XP_038937350.1 NLR family member X1 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ8

UniProtKB/TrEMBL

A6J3W5

Conserved Domains (3) summary

sd00033
Location:696 → 724

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:696 → 901

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:159 → 318

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_039081423.2 → XP_038937351.1 NLR family member X1 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ8

UniProtKB/TrEMBL

A6J3W5

Conserved Domains (3) summary

sd00033
Location:696 → 724

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:696 → 901

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:159 → 318

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_039081424.2 → XP_038937352.1 NLR family member X1 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ8

UniProtKB/TrEMBL

A6J3W5

Conserved Domains (3) summary

sd00033
Location:696 → 724

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:696 → 901

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:159 → 318

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases