Enho energy homeostasis associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Enhoprovided by RGD
Official Full Name: energy homeostasis associatedprovided by RGD
Primary source: RGD:6487582
See related: EnsemblRapid:ENSRNOG00000043300 AllianceGenome:RGD:6487582
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565232
Summary: Predicted to enable hormone activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be active in plasma membrane. Orthologous to human ENHO (energy homeostasis associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 162.0), Muscle (RPKM 18.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (61596860..61598657, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56800980..56802777, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (58018039..58019836, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus.
Title: Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus.
Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model.
Title: Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model.
Adropin increases with swimming exercise and exerts a protective effect on the brain of aged rats.
Title: Adropin increases with swimming exercise and exerts a protective effect on the brain of aged rats.
The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats.
Title: The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats.
Adropin stimulates proliferation but suppresses differentiation in rat primary brown preadipocytes.
Title: Adropin stimulates proliferation but suppresses differentiation in rat primary brown preadipocytes.
Adropin reduced lipid accumulation as well as expression of proadipogenic genes in 3T3-L1 cells and rat preadipocytes, suggesting that this protein attenuates differentiation of preadipocytes into mature fat cells. In summary, these results show that adropin modulates proliferation and differentiation of preadipocytes.
Title: Effects of adropin on proliferation and differentiation of 3T3-L1 cells and rat primary preadipocytes.
Adropin-mediated GPR19 signaling relies on the p44/42 MAPK pathway.
Title: Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.
The neuroprotective effects of ischemic preconditioning in middle cerebral artery infarcts correlated with the level of oxidative damage markers and adropin.
Title: Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats.
The findings elucidate the pathogenesis of MI, and the gradual increase in serum adropin could be a novel diagnostic marker and serve as an alternative to troponin-I measurement for diagnosing MI.
Title: Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
Data show that adropin (ADR) is expressed in various tissues in the rats and its levels increased in STZ-induced diabetes.
Title: Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adropin

Names: adropin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.