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    RragB Ras-related GTP binding B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RragBprovided by RGD
    Official Full Name
    Ras-related GTP binding Bprovided by RGD
    Primary source
    RGD:619805
    See related
    EnsemblRapid:ENSRNOG00000062421 AllianceGenome:RGD:619805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ragb
    Summary
    Enables GTP binding activity. Predicted to be involved in several processes, including cellular response to leucine starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGB (Ras related GTP binding B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 134.5), Adrenal (RPKM 27.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See RragB in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (21560313..21610550, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (18184619..18234639, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (19085913..19135049, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ubiquilin 2 Neighboring gene KLF transcription factor 8 Neighboring gene ribosomal protein L35, pseudogene 8 Neighboring gene uncharacterized LOC100909694 Neighboring gene forkhead box R2 Neighboring gene MAGE family member H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. Schürmann A, et al. J Biol Chem, 1995 Dec 1. PMID 7499430
    2. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. Hirose E, et al. J Cell Sci, 1998 Jan. PMID 9394008
    3. Molecular cloning and characterization of six cDNAs expressed during glucose starvation in excised maize (Zea mays L.) root tips. Chevalier C, et al. Plant Mol Biol, 1995 Jun. PMID 7632917
    4. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Kim YM, et al. Mol Cell, 2012 Jun 29. PMID 22575674, Free PMC Article
    5. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105357

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl ribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl ribonucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related GTP-binding protein B
    Names
    GTP-binding protein ragB
    rag B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053972.3 → NP_446424.1  ras-related GTP-binding protein B

      See identical proteins and their annotated locations for NP_446424.1

      Status: VALIDATED

      Source sequence(s)
      BC087698
      UniProtKB/Swiss-Prot
      Q63487, Q6AZ37
      UniProtKB/TrEMBL
      A0A8I5ZR61, A6KL60
      Related
      ENSRNOP00000004235.3, ENSRNOT00000004235.8
      Conserved Domains (1) summary
      cd11384
      Location:42 → 353
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      21560313..21610550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279758.1 → XP_063135828.1  ras-related GTP-binding protein B isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y9L7
      Related
      ENSRNOP00000077577.2, ENSRNOT00000117263.2

    2. XM_063279757.1 → XP_063135827.1  ras-related GTP-binding protein B isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9L7

    3. XM_039099416.2 → XP_038955344.1  ras-related GTP-binding protein B isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9L7
      Conserved Domains (1) summary
      cd11384
      Location:42 → 342
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    4. XM_008773109.4 → XP_008771331.2  ras-related GTP-binding protein B isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9L7, A0A8L2QXU5
      Related
      ENSRNOP00000066990.2, ENSRNOT00000075249.5
      Conserved Domains (1) summary
      cd11384
      Location:42 → 344
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    5. XM_006256775.5 → XP_006256837.1  ras-related GTP-binding protein B isoform X2

      See identical proteins and their annotated locations for XP_006256837.1

      UniProtKB/TrEMBL
      A0A8I5ZR61, A6KL59
      Related
      ENSRNOP00000108946.1, ENSRNOT00000126370.1
      Conserved Domains (1) summary
      cd11384
      Location:42 → 325
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63487.1 GenPept UniProtKB/Swiss-Prot:Q63487

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