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    Bmp5 bone morphogenetic protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315824, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmp5provided by RGD
    Official Full Name
    bone morphogenetic protein 5provided by RGD
    Primary source
    RGD:1305979
    See related
    EnsemblRapid:ENSRNOG00000010917 AllianceGenome:RGD:1305979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including chordate embryonic development; heart development; and negative regulation of steroid hormone biosynthetic process. Predicted to act upstream of or within several processes, including anterior head development; ear development; and male genitalia development. Located in extracellular space and vesicle. Orthologous to human BMP5 (bone morphogenetic protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 42.9), Lung (RPKM 37.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Bmp5 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (85397629..85520374)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (76517164..76639925)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82669466..82950273)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene secretogranin III Neighboring gene uncharacterized LOC120094210 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase like 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene GDNF family receptor alpha like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP receptor binding  
    enables cytokine activity  
    enables growth factor activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in allantois development  
    acts_upstream_of_or_within anterior head development  
    involved_in cardiac muscle tissue development  
    involved_in cardiac septum morphogenesis  
    involved_in chorio-allantoic fusion  
    acts_upstream_of_or_within ear development  
    involved_in endocardial cushion formation  
    involved_in heart trabecula morphogenesis  
    involved_in hindbrain development  
    acts_upstream_of_or_within male genitalia development  
    involved_in negative regulation of aldosterone biosynthetic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cortisol biosynthetic process  
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway  
    involved_in negative regulation of steroid biosynthetic process  
    involved_in neural fold elevation formation  
    acts_upstream_of_or_within pattern specification process  
    involved_in pericardium morphogenesis  
    involved_in pharyngeal system development  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of dendrite development  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal system development  
    involved_in type B pancreatic cell development  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    bone morphogenetic protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108168.1 → NP_001101638.1  bone morphogenetic protein 5 precursor

      See identical proteins and their annotated locations for NP_001101638.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I1F0, D4A7P9
      Related
      ENSRNOP00000014846.5, ENSRNOT00000014846.7
      Conserved Domains (2) summary
      smart00204
      Location:353 → 454
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:31 → 304
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      85397629..85520374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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