Unc5c unc-5 netrin receptor C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc5cprovided by RGD
Official Full Name: unc-5 netrin receptor Cprovided by RGD
Primary source: RGD:735109
See related: EnsemblRapid:ENSRNOG00000029071 AllianceGenome:RGD:735109
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable netrin receptor activity involved in chemorepulsion; protein kinase binding activity; and tubulin binding activity. Predicted to be involved in chemorepulsion of axon; dorsal root ganglion development; and netrin-activated signaling pathway. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of apoptotic process; and regulation of neuron migration. Predicted to be located in several cellular components, including filopodium; growth cone; and lamellipodium. Orthologous to human UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 82.8), Adrenal (RPKM 75.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (232854352..233208482)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (230180353..230535219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (247045813..247397483)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T835M (rs137875858) in UNC5C increased hippocampal neuronal cell death and susceptibility to neurotoxic stimuli.
Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Both cvd and hob mutations are predicted to lead to truncated UNC5H3 proteins lacking their cytoplasmic region required for Netrin-Unc5h3 signaling pathway. Therefore, we conclude that Unc5h3 is causative gene of both cvd and hob mutant phenotypes.
Title: Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.

Submit: New GeneRIF Correction

General gene information

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Markers

AU049740 (e-PCR)
- UniSTS:146186

Unc5c (e-PCR), detects polymorphism
- UniSTS:526928

Unc5c (e-PCR), detects polymorphism
- UniSTS:526931

D2Rat296 (e-PCR), detects polymorphism
- UniSTS:227431

RH138265 (e-PCR)
- UniSTS:220352

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables netrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity	ISO Inferred from Sequence Orthology more info
enables netrin receptor activity involved in chemorepulsion	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity involved in chemorepulsion	ISO Inferred from Sequence Orthology more info
enables netrin receptor activity involved in chemorepulsion	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axon guidance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in chemorepulsion of axon	IEA Inferred from Electronic Annotation more info
involved_in chemorepulsion of axon	ISO Inferred from Sequence Orthology more info
involved_in chemorepulsion of axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in dorsal root ganglion development	IEA Inferred from Electronic Annotation more info
involved_in dorsal root ganglion development	ISO Inferred from Sequence Orthology more info
involved_in dorsal root ganglion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ectopic germ cell programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of developmental process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reproductive process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of reproductive process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin receptor UNC5C

Names: protein unc-5 homolog 3; protein unc-5 homolog C; unc-5 homolog 3; unc-5 homolog C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415084.1 → NP_001402013.1 netrin receptor UNC5C isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q761X5

UniProtKB/TrEMBL

A0A8I6AEG2

Related

ENSRNOP00000090774.1, ENSRNOT00000106798.2
NM_199407.2 → NP_955439.2 netrin receptor UNC5C isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q761X5

UniProtKB/TrEMBL

A0A8I6AAJ4, A6HW54

Related

ENSRNOP00000089543.1, ENSRNOT00000108186.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

232854352..233208482

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102727.2 → XP_038958655.1 netrin receptor UNC5C isoform X1

UniProtKB/TrEMBL

A0A8I6GH52

Conserved Domains (6) summary

smart00218
Location:433 → 536

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:149 → 200

TSP1; Thrombospondin type 1 repeats

cd08799
Location:749 → 831

Death_UNC5C; Death domain found in Uncoordinated-5C

pfam17217
Location:583 → 722

UPA; UPA domain

cd00096
Location:61 → 65

Ig; Ig strand A' [structural motif]

cl11960
Location:57 → 143

Ig; Immunoglobulin domain
XM_039102728.2 → XP_038958656.1 netrin receptor UNC5C isoform X2

UniProtKB/TrEMBL

F1LM73

Related

ENSRNOP00000050380.6, ENSRNOT00000050330.7

Conserved Domains (6) summary

smart00218
Location:406 → 509

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:122 → 173

TSP1; Thrombospondin type 1 repeats

cd08799
Location:722 → 804

Death_UNC5C; Death domain found in Uncoordinated-5C

pfam17217
Location:556 → 695

UPA; UPA domain

cd00096
Location:34 → 38

Ig; Ig strand A' [structural motif]

cl11960
Location:30 → 116

Ig; Immunoglobulin domain
XM_039102729.2 → XP_038958657.1 netrin receptor UNC5C isoform X3

UniProtKB/TrEMBL

A0A8I6A7B2, F1LM73

Related

ENSRNOP00000105184.1, ENSRNOT00000165460.1

Conserved Domains (6) summary

smart00218
Location:403 → 506

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:119 → 170

TSP1; Thrombospondin type 1 repeats

cd08799
Location:719 → 801

Death_UNC5C; Death domain found in Uncoordinated-5C

pfam17217
Location:553 → 692

UPA; UPA domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:27 → 113

Ig; Immunoglobulin domain