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    D2hgdh D-2-hydroxyglutarate dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301624, updated on 9-Dec-2024

    Summary

    Official Symbol
    D2hgdhprovided by RGD
    Official Full Name
    D-2-hydroxyglutarate dehydrogenaseprovided by RGD
    Primary source
    RGD:1307976
    See related
    EnsemblRapid:ENSRNOG00000019012 AllianceGenome:RGD:1307976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307976
    Summary
    Enables (R)-2-hydroxyglutarate dehydrogenase activity. Involved in response to cobalt ion; response to manganese ion; and response to zinc ion. Located in mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.6), Adrenal (RPKM 98.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See D2hgdh in Genome Data Viewer
    Location:
    9q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101796287..101815727)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94350555..94368384)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100956570..100974393)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene deoxythymidylate kinase Neighboring gene inhibitor of growth family, member 5 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene neuraminidase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (R)-2-hydroxyglutarate dehydrogenase activity PubMed 
    enables (R)-2-hydroxyglutarate dehydrogenase activity  
    enables (R)-2-hydroxyglutarate dehydrogenase activity  
    enables FAD binding  
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    D-2-hydroxyglutarate dehydrogenase, mitochondrial
    NP_001100396.2
    XP_006245582.1
    XP_006245583.1
    XP_006245584.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106926.2NP_001100396.2  D-2-hydroxyglutarate dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P84850
      UniProtKB/TrEMBL
      A6JR40, B2GV75
      Conserved Domains (1) summary
      COG0277
      Location:90532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101796287..101815727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245520.4XP_006245582.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8L2R544, A6JR40
      Related
      ENSRNOP00000071036.2, ENSRNOT00000078222.3
      Conserved Domains (3) summary
      COG0277
      Location:108550
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:133270
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:307547
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain
    2. XM_006245522.5XP_006245584.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006245584.1

      UniProtKB/Swiss-Prot
      P84850
      UniProtKB/TrEMBL
      A6JR40, B2GV75
      Conserved Domains (1) summary
      COG0277
      Location:90532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    3. XM_006245521.5XP_006245583.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006245583.1

      UniProtKB/Swiss-Prot
      P84850
      UniProtKB/TrEMBL
      A6JR40, B2GV75
      Conserved Domains (1) summary
      COG0277
      Location:90532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    RNA

    1. XR_005488880.2 RNA Sequence

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