Crbn cereblon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crbnprovided by RGD
Official Full Name: cereblonprovided by RGD
Primary source: RGD:1310533
See related: EnsemblRapid:ENSRNOG00000006534 AllianceGenome:RGD:1310533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables transmembrane transporter binding activity. Involved in negative regulation of monoatomic ion transmembrane transport; negative regulation of protein-containing complex assembly; and positive regulation of protein-containing complex assembly. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 308.6), Adrenal (RPKM 267.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (141255400..141276722, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (139701154..139719949, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (138864910..138885786, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aerobic exercise training decreases cereblon level in the skeletal muscle of diabetic rats.
Title: Aerobic exercise training decreases cereblon and increases AMPK signaling in the skeletal muscle of STZ-induced diabetic rats.
In neonatal cardiomyocytes, overexpression of CRBN significantly reduced AMPK activity, as demonstrated by reductions in both phosphorylation levels of AMPK and the expression of its downstream target genes.
Title: Ablation of cereblon attenuates myocardial ischemia-reperfusion injury.
CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation.
Title: Functional modulation of AMP-activated protein kinase by cereblon.
Crbn is expressed in the retina and binds to voltage-gated chloride channels.
Title: Cereblon is expressed in the retina and binds to voltage-gated chloride channels.
CRBN may play an important role in assembly and surface expression of functional BK(Ca) channels by direct interaction with the cytosolic C-terminus of its alpha-subunit.
Title: Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143319 (e-PCR)
- UniSTS:232566

RH131416 (e-PCR)
- UniSTS:214699

RH132465 (e-PCR)
- UniSTS:215748

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of large conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein cereblon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015003.2 → NP_001015003.1 protein cereblon

See identical proteins and their annotated locations for NP_001015003.1

Status: VALIDATED

Source sequence(s)

BC099779, CB567139, JAXUCZ010000004

UniProtKB/Swiss-Prot

A1L110, Q499S7, Q56AP7

UniProtKB/TrEMBL

A6IBK3

Related

ENSRNOP00000008873.4, ENSRNOT00000008873.6

Conserved Domains (2) summary

cd15777
Location:324 → 425

CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains

pfam02190
Location:83 → 320

LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain