Adh6a alcohol dehydrogenase 6A (class V) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adh6aprovided by RGD
Official Full Name: alcohol dehydrogenase 6A (class V)provided by RGD
Primary source: RGD:1310029
See related: EnsemblRapid:ENSRNOG00000012281 AllianceGenome:RGD:1310029
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and zinc ion binding activity. Predicted to be involved in retinoic acid metabolic process and retinol metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 6.0), Uterus (RPKM 3.3) and 6 other tissues See more
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229497121..229519403)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226823775..226846005)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243577086..243599357)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alcohol dehydrogenase 6A (class V)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106475.1 → NP_001099945.1 alcohol dehydrogenase 6A (class V)

See identical proteins and their annotated locations for NP_001099945.1

Status: PROVISIONAL

Source sequence(s)

CH473952

UniProtKB/TrEMBL

A6HW30

Conserved Domains (2) summary

COG1062
Location:1 → 335

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

cl16912
Location:1 → 335

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family