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    Vps8 VPS8 subunit of CORVET complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps8provided by RGD
    Official Full Name
    VPS8 subunit of CORVET complexprovided by RGD
    Primary source
    RGD:1309443
    See related
    EnsemblRapid:ENSRNOG00000001764 AllianceGenome:RGD:1309443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309443
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Predicted to be part of CORVET complex and HOPS complex. Predicted to be active in early endosome and late endosome. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 99.2), Kidney (RPKM 85.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps8 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (92906702..93140844, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (79402236..79634234, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83104912..83323606, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352384 Neighboring gene similar to human chromosome 3 open reading frame 70 Neighboring gene uncharacterized LOC108352385 Neighboring gene uncharacterized LOC120095695 Neighboring gene SNW domain containing 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Perini ED, et al. Traffic, 2014 Dec. PMID 25266290
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CORVET complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 8 homolog
    Names
    VPS8 CORVET complex subunit
    vacuolar protein sorting 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427620.1 → NP_001414549.1  vacuolar protein sorting-associated protein 8 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AEY8
      Related
      ENSRNOP00000077953.2, ENSRNOT00000110575.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      92906702..93140844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270364.1 → XP_063126434.1  vacuolar protein sorting-associated protein 8 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEY8
      Related
      ENSRNOP00000105239.1, ENSRNOT00000157844.1

    2. XM_063270362.1 → XP_063126432.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEY8

    3. XM_063270366.1 → XP_063126436.1  vacuolar protein sorting-associated protein 8 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEY8
      Related
      ENSRNOP00000100644.1, ENSRNOT00000125353.1

    4. XM_063270363.1 → XP_063126433.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEY8

    5. XM_063270361.1 → XP_063126431.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEY8

    6. XM_063270365.1 → XP_063126435.1  vacuolar protein sorting-associated protein 8 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEY8
    Nucleotide Protein Strain
    Heading Accession and Version

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