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    Aven apoptosis and caspase activation inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Avenprovided by RGD
    Official Full Name
    apoptosis and caspase activation inhibitorprovided by RGD
    Primary source
    RGD:1309928
    See related
    EnsemblRapid:ENSRNOG00000006419 AllianceGenome:RGD:1309928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of apoptotic process. Predicted to be located in membrane. Orthologous to human AVEN (apoptosis and caspase activation inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 240.1), Muscle (RPKM 151.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aven in Genome Data Viewer
    Location:
    3q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119753395..119886009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99299009..99431635)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103980612..104117193)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L19-like Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene proteasome subunit beta type-3-like Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene ryanodine receptor 3 Neighboring gene uncharacterized LOC120101913 Neighboring gene uncharacterized LOC108350585

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Li X, et al. Mol Med Rep, 2022 Aug. PMID 35795990, Free PMC Article
    2. Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis. Laurentino S, et al. Fertil Steril, 2011 Sep. PMID 21718987
    3. Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury. Ozisik K, et al. Transplant Proc, 2006 Nov. PMID 17112829
    4. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Chau BN, et al. Mol Cell, 2000 Jul. PMID 10949025
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR488 and regulating AVEN expression.
      Title: Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression.
    2. The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility.
      Title: Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis.
    3. Both erythropoitin and methylprednisolone may play important roles in the expression of antiapoptotic survivin and aven genes in heart tissue after traumatic brain injury.
      Title: Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell death regulator Aven
    Names
    apoptosis, caspase activation inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399518.1 → NP_001386447.1  cell death regulator Aven

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AHX5, A6HP55

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119753395..119886009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234707.5 → XP_006234769.1  cell death regulator Aven isoform X1

      See identical proteins and their annotated locations for XP_006234769.1

      UniProtKB/TrEMBL
      A0A8I6AHX5, A6HP55

    2. XM_039104935.2 → XP_038960863.1  cell death regulator Aven isoform X2

      UniProtKB/TrEMBL
      A0A8I6G485, A6HP56, A6HP57, D3Z853

    3. XM_063283708.1 → XP_063139778.1  cell death regulator Aven isoform X2

      UniProtKB/TrEMBL
      A0A8I6G485, A6HP56, A6HP57, D3Z853
      Related
      ENSRNOP00000078951.1, ENSRNOT00000110947.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107757.1: Suppressed sequence

      Description
      NM_001107757.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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