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    Faap24 FA core complex associated protein 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faap24provided by RGD
    Official Full Name
    FA core complex associated protein 24provided by RGD
    Primary source
    RGD:1564719
    See related
    EnsemblRapid:ENSRNOG00000022393 AllianceGenome:RGD:1564719
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564719
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in interstrand cross-link repair. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Orthologous to human FAAP24 (FA core complex associated protein 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 40.9), Kidney (RPKM 39.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Faap24 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97188678..97194899, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88051523..88057997, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91657263..91663485, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G patch domain containing 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G like 1 Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene centrosomal protein 89 Neighboring gene solute carrier family 7 member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Singh TR, et al. Mol Cell, 2010 Mar 26. PMID 20347429, Free PMC Article
    2. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, et al. Mol Cell, 2010 Mar 26. PMID 20347428, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi anemia core complex-associated protein 24
    Names
    Fanconi anemia core complex associated protein 24
    Fanconi anemia-associated protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109335.1 → NP_001102805.1  Fanconi anemia core complex-associated protein 24

      See identical proteins and their annotated locations for NP_001102805.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6JAA9, D3ZE71
      Related
      ENSRNOP00000031862.3, ENSRNOT00000033396.5
      Conserved Domains (1) summary
      pfam12826
      Location:166 → 218
      HHH_2; Helix-hairpin-helix motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      97188678..97194899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088338.2 → XP_038944266.1  Fanconi anemia core complex-associated protein 24 isoform X2

      Conserved Domains (2) summary
      pfam12826
      Location:98 → 150
      HHH_2; Helix-hairpin-helix motif
      cl41760
      Location:14 → 71
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    2. XM_006228896.5 → XP_006228958.1  Fanconi anemia core complex-associated protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006228958.1

      UniProtKB/TrEMBL
      A6JAA9, D3ZE71
      Conserved Domains (1) summary
      pfam12826
      Location:166 → 218
      HHH_2; Helix-hairpin-helix motif
    Nucleotide Protein Strain
    Heading Accession and Version

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