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    Rbpms2 RNA binding protein, mRNA processing factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbpms2provided by RGD
    Official Full Name
    RNA binding protein, mRNA processing factor 2provided by RGD
    Primary source
    RGD:1561222
    See related
    EnsemblRapid:ENSRNOG00000015896 AllianceGenome:RGD:1561222
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561222
    Summary
    Predicted to enable mRNA binding activity and protein homodimerization activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 94.3), Heart (RPKM 63.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbpms2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75048159..75079393)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66153169..66184278)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71165375..71200299)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing O2 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of hermes gene is restricted to the ganglion cells in the retina. Piri N, et al. Neurosci Lett, 2006 Sep 11. PMID 16870336
    2. Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers. Nakagaki-Silva EE, et al. Elife, 2019 Jul 8. PMID 31283468, Free PMC Article
    3. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. Sagnol S, et al. Nucleic Acids Res, 2014 Sep. PMID 25064856, Free PMC Article
    4. Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators. Yang Y, et al. Nucleic Acids Res, 2023 Oct 13. PMID 37548402, Free PMC Article
    5. Mapping the in vitro interactome of cardiac sodium (Na(+) )-calcium (Ca(2+) ) exchanger 1 (NCX1). Lubelwana Hafver T, et al. Proteomics, 2017 Sep. PMID 28755400

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189424

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding protein, mRNA processing factor 2; RNA-binding protein with multiple splicing 2
    Names
    RNA binding protein with multiple splicing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173426.1 → NP_001166897.1  RNA binding protein, mRNA processing factor 2

      See identical proteins and their annotated locations for NP_001166897.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169038
      UniProtKB/Swiss-Prot
      B5DFF2, F1M9N3
      Conserved Domains (1) summary
      cd12683
      Location:30 → 105
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75048159..75079393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243274.5 → XP_006243336.1  RNA-binding protein with multiple splicing 2 isoform X1

      See identical proteins and their annotated locations for XP_006243336.1

      UniProtKB/Swiss-Prot
      B5DFF2, F1M9N3
      Related
      ENSRNOP00000021337.6, ENSRNOT00000021337.9
      Conserved Domains (1) summary
      cd12683
      Location:30 → 105
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DFF2.1 GenPept UniProtKB/Swiss-Prot:B5DFF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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