Gprc5a G protein-coupled receptor, class C, group 5, member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gprc5aprovided by RGD
Official Full Name: G protein-coupled receptor, class C, group 5, member Aprovided by RGD
Primary source: RGD:1310804
See related: EnsemblRapid:ENSRNOG00000008412 AllianceGenome:RGD:1310804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rai3
Summary: Predicted to enable protein kinase activator activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in nucleolus and vesicle. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human GPRC5A (G protein-coupled receptor class C group 5 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 605.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (169634896..169653627)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (167903542..167922276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (168832937..168851650)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gprc5a (e-PCR), detects polymorphism
- UniSTS:536578

BI302197 (e-PCR)
- UniSTS:247577

BF414790 (e-PCR)
- UniSTS:248750

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoic acid-induced protein 3

Names: G protein-coupled receptor, family C, group 5, member A; retinoic acid induced 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.