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    Catsperz catsper channel auxiliary subunit zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Catsperzprovided by RGD
    Official Full Name
    catsper channel auxiliary subunit zetaprovided by RGD
    Primary source
    RGD:2318763
    See related
    EnsemblRapid:ENSRNOG00000089798 AllianceGenome:RGD:2318763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tex40
    Summary
    Predicted to be involved in flagellated sperm motility; male meiotic nuclear division; and sperm capacitation. Predicted to be located in cytoplasm and sperm principal piece. Predicted to be part of CatSper complex. Orthologous to human CATSPERZ (catsper channel auxiliary subunit zeta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 380.1) and Brain (RPKM 39.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Catsperz in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213544032..213547326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204114816..204118582, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222179451..222182716, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 5 Neighboring gene tRNA methyltransferase activator subunit 11-2 Neighboring gene estrogen related receptor, alpha Neighboring gene uncharacterized LOC134483962 Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene G protein-coupled receptor 137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Hwang JY, et al. Cell, 2019 May 30. PMID 31056283, Free PMC Article
    2. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Chung JJ, et al. Elife, 2017 Feb 23. PMID 28226241, Free PMC Article
    3. Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. Kogo H, et al. J Hum Genet, 2010 May. PMID 20339383
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit zeta; catsper channel auxiliary subunit zeta
    Names
    cation channel sperm-associated protein subunit zeta
    rCG47836-like
    testis expressed 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432734.1 → NP_001419663.1  catsper channel auxiliary subunit zeta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NM_001432735.1 → NP_001419664.1  catsper channel auxiliary subunit zeta isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K360

    3. NM_001432736.1 → NP_001419665.1  catsper channel auxiliary subunit zeta isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HZJ5

    4. NM_001432737.1 → NP_001419666.1  catsper channel auxiliary subunit zeta isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RNA

    1. NR_197303.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NR_197304.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    3. NR_197305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213544032..213547326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279957.1 → XP_063136027.1  cation channel sperm-associated auxiliary subunit zeta isoform X10

    2. XM_063279954.1 → XP_063136024.1  cation channel sperm-associated auxiliary subunit zeta isoform X9

    3. XM_063279947.1 → XP_063136017.1  cation channel sperm-associated auxiliary subunit zeta isoform X6

    4. XM_063279939.1 → XP_063136009.1  cation channel sperm-associated auxiliary subunit zeta isoform X4

      Related
      ENSRNOP00000105768.1, ENSRNOT00000154998.1

    5. XM_063279935.1 → XP_063136005.1  cation channel sperm-associated auxiliary subunit zeta isoform X2

    6. XM_063279952.1 → XP_063136022.1  cation channel sperm-associated auxiliary subunit zeta isoform X8

    7. XM_063279951.1 → XP_063136021.1  cation channel sperm-associated auxiliary subunit zeta isoform X7

    8. XM_063279944.1 → XP_063136014.1  cation channel sperm-associated auxiliary subunit zeta isoform X5

    9. XM_063279936.1 → XP_063136006.1  cation channel sperm-associated auxiliary subunit zeta isoform X3

    10. XM_063279933.1 → XP_063136003.1  cation channel sperm-associated auxiliary subunit zeta isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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