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    Stim1 stromal interaction molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361618, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stim1provided by RGD
    Official Full Name
    stromal interaction molecule 1provided by RGD
    Primary source
    RGD:1306831
    See related
    EnsemblRapid:ENSRNOG00000020425 AllianceGenome:RGD:1306831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium channel regulator activity and store-operated calcium channel activity. Involved in activation of store-operated calcium channel activity; regulation of store-operated calcium entry; and store-operated calcium entry. Located in growth cone. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 263.7), Thymus (RPKM 179.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stim1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166067450..166230733)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156656246..156818777)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167373894..167533412)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ras homolog family member G Neighboring gene ribosomal protein S29, pseudogene 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene ribonucleotide reductase catalytic subunit M1 Neighboring gene olfactory receptor family 55 subfamily B member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity  
    enables calcium channel regulator activity  
    enables calcium channel regulator activity PubMed 
    enables calcium channel regulator activity  
    enables calcium channel regulator activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables channel activator activity  
    enables identical protein binding  
    enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway  
    enables metal ion binding  
    enables microtubule plus-end binding  
    enables microtubule plus-end binding  
    enables protease binding  
    enables store-operated calcium channel activity PubMed 
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity PubMed 
    involved_in activation of store-operated calcium channel activity  
    involved_in activation of store-operated calcium channel activity  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport  
    involved_in detection of calcium ion  
    involved_in detection of calcium ion  
    involved_in enamel mineralization  
    involved_in enamel mineralization  
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in intracellular calcium ion homeostasis  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
    involved_in ligand-gated ion channel signaling pathway  
    acts_upstream_of_or_within monoatomic cation transport  
    acts_upstream_of_or_within myotube differentiation  
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of adenylate cyclase activity  
    involved_in positive regulation of adenylate cyclase activity  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of insulin secretion  
    involved_in regulation of calcium ion transport  
    involved_in regulation of calcium ion transport  
    involved_in regulation of store-operated calcium entry PubMed 
    involved_in regulation of store-operated calcium entry  
    involved_in regulation of store-operated calcium entry  
    involved_in regulation of transport  
    involved_in store-operated calcium entry  
    involved_in store-operated calcium entry PubMed 
    involved_in store-operated calcium entry PubMed 
    acts_upstream_of_or_within store-operated calcium entry  
    involved_in store-operated calcium entry  
    involved_in store-operated calcium entry  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in growth cone PubMed 
    located_in microtubule  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft  
    located_in plasma membrane raft  
    located_in sarcoplasmic reticulum membrane  
    located_in sarcoplasmic reticulum membrane  
    located_in synapse  

    General protein information

    Preferred Names
    stromal interaction molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108496.2NP_001101966.2  stromal interaction molecule 1 precursor

      See identical proteins and their annotated locations for NP_001101966.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/Swiss-Prot
      P84903
      UniProtKB/TrEMBL
      A6I737
      Conserved Domains (3) summary
      cd09573
      Location:128201
      SAM_STIM1; SAM domain of STIM1 subfamily proteins
      COG1196
      Location:237434
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16533
      Location:344441
      SOAR; STIM1 Orai1-activating region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      166067450..166230733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267236.1XP_063123306.1  stromal interaction molecule 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5C8
    2. XM_063267232.1XP_063123302.1  stromal interaction molecule 1 isoform X2

      UniProtKB/TrEMBL
      A6I736
      Related
      ENSRNOP00000110413.1, ENSRNOT00000125071.1
    3. XM_063267252.1XP_063123322.1  stromal interaction molecule 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K5C8, A0A8L2QER8
      Related
      ENSRNOP00000027685.5, ENSRNOT00000027685.7
    4. XM_063267229.1XP_063123299.1  stromal interaction molecule 1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWQ1
      Related
      ENSRNOP00000075979.2, ENSRNOT00000092882.3
    5. XM_063267233.1XP_063123303.1  stromal interaction molecule 1 isoform X3

      UniProtKB/Swiss-Prot
      P84903
      UniProtKB/TrEMBL
      A6I737
    6. XM_063267242.1XP_063123312.1  stromal interaction molecule 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5C8
    7. XM_063267260.1XP_063123330.1  stromal interaction molecule 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K5C8
      Related
      ENSRNOP00000107460.1, ENSRNOT00000135173.1
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