Mast3 microtubule associated serine/threonine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mast3provided by RGD
Official Full Name: microtubule associated serine/threonine kinase 3provided by RGD
Primary source: RGD:1587639
See related: EnsemblRapid:ENSRNOG00000022753 AllianceGenome:RGD:1587639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 46.9), Spleen (RPKM 33.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18670742..18699252)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18636764..18663852)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20387330..20414767)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In an experimental arthritis model, we successfully explored the effect of MAST3 on inflammatory response and proliferation of fibroblast-like synovial cells(FLSs) in vitro. In synovial tissues of inflamed joints as well as in FLSs, we explored that the expression of MAST3 was significantly increased. Silencing or overexpressing of MAST3 was involved in the process of proliferation and inflammatory response of FLSs.
Title: MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
MAST3 shows selective expression in the striatum and cerebral cortex of rats.
Title: Expression of the MAST family of serine/threonine kinases.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 3

NP_001128268.1

EC 2.7.11.1

XP_006253005.1

EC 2.7.11.1

XP_006253006.1

EC 2.7.11.1

XP_006253007.1

EC 2.7.11.1

XP_006253008.1

EC 2.7.11.1

XP_006253009.1

EC 2.7.11.1

XP_008769376.1

EC 2.7.11.1

XP_038950759.1

EC 2.7.11.1

XP_038950760.1

EC 2.7.11.1

XP_038950763.1

EC 2.7.11.1

XP_038950764.1

EC 2.7.11.1

XP_038950765.1

EC 2.7.11.1

XP_038950766.1

EC 2.7.11.1

XP_063131804.1

EC 2.7.11.1

XP_063131805.1

EC 2.7.11.1

XP_063131806.1

EC 2.7.11.1

XP_063131807.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134796.1 → NP_001128268.1 microtubule-associated serine/threonine-protein kinase 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D3ZL30

Related

ENSRNOP00000105483.1, ENSRNOT00000170834.1

Conserved Domains (4) summary

smart00220
Location:373 → 646

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:955 → 1032

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:372 → 651

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18670742..18699252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252945.5 → XP_006253007.1 microtubule-associated serine/threonine-protein kinase 3 isoform X11

Conserved Domains (4) summary

smart00220
Location:374 → 647

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:956 → 1033

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:373 → 652

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 338

DUF1908; Domain of unknown function (DUF1908)
XM_063275734.1 → XP_063131804.1 microtubule-associated serine/threonine-protein kinase 3 isoform X5

UniProtKB/TrEMBL

A0A0G2JVL3

Related

ENSRNOP00000069529.1, ENSRNOT00000078108.3
XM_039094831.2 → XP_038950759.1 microtubule-associated serine/threonine-protein kinase 3 isoform X1

Conserved Domains (3) summary

cd00992
Location:987 → 1064

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:404 → 683

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:89 → 369

DUF1908; Domain of unknown function (DUF1908)
XM_039094835.2 → XP_038950763.1 microtubule-associated serine/threonine-protein kinase 3 isoform X3

Related

ENSRNOP00000087389.2, ENSRNOT00000115023.2

Conserved Domains (3) summary

cd00992
Location:980 → 1057

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:397 → 676

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:89 → 362

DUF1908; Domain of unknown function (DUF1908)
XM_039094832.2 → XP_038950760.1 microtubule-associated serine/threonine-protein kinase 3 isoform X2

Conserved Domains (3) summary

cd00992
Location:986 → 1063

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:403 → 682

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:88 → 368

DUF1908; Domain of unknown function (DUF1908)
XM_039094836.2 → XP_038950764.1 microtubule-associated serine/threonine-protein kinase 3 isoform X4

Related

ENSRNOP00000090852.2, ENSRNOT00000116599.2

Conserved Domains (3) summary

cd00992
Location:979 → 1056

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:396 → 675

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:88 → 361

DUF1908; Domain of unknown function (DUF1908)
XM_006252947.5 → XP_006253009.1 microtubule-associated serine/threonine-protein kinase 3 isoform X14

Conserved Domains (4) summary

smart00220
Location:367 → 640

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:949 → 1026

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:366 → 645

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 331

DUF1908; Domain of unknown function (DUF1908)
XM_039094838.2 → XP_038950766.1 microtubule-associated serine/threonine-protein kinase 3 isoform X12

UniProtKB/TrEMBL

A0A8I6A5R8

Conserved Domains (3) summary

cd00992
Location:955 → 1032

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:372 → 651

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_063275737.1 → XP_063131807.1 microtubule-associated serine/threonine-protein kinase 3 isoform X15
XM_063275735.1 → XP_063131805.1 microtubule-associated serine/threonine-protein kinase 3 isoform X6
XM_006252943.5 → XP_006253005.1 microtubule-associated serine/threonine-protein kinase 3 isoform X7

UniProtKB/TrEMBL

A0A8I6GIK5

Conserved Domains (4) summary

smart00220
Location:390 → 663

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:972 → 1049

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:389 → 668

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:81 → 354

DUF1908; Domain of unknown function (DUF1908)
XM_063275736.1 → XP_063131806.1 microtubule-associated serine/threonine-protein kinase 3 isoform X8

UniProtKB/TrEMBL

A6K9Z8
XM_008771154.4 → XP_008769376.1 microtubule-associated serine/threonine-protein kinase 3 isoform X16

Conserved Domains (4) summary

smart00220
Location:372 → 645

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:954 → 1031

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:371 → 650

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:63 → 336

DUF1908; Domain of unknown function (DUF1908)
XM_006252944.5 → XP_006253006.1 microtubule-associated serine/threonine-protein kinase 3 isoform X9

Related

ENSRNOP00000034796.5, ENSRNOT00000037756.6

Conserved Domains (4) summary

smart00220
Location:380 → 653

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:962 → 1039

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:379 → 658

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 344

DUF1908; Domain of unknown function (DUF1908)
XM_039094837.2 → XP_038950765.1 microtubule-associated serine/threonine-protein kinase 3 isoform X10

Conserved Domains (3) summary

cd00992
Location:961 → 1038

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:378 → 657

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:63 → 343

DUF1908; Domain of unknown function (DUF1908)
XM_006252946.5 → XP_006253008.1 microtubule-associated serine/threonine-protein kinase 3 isoform X13

Conserved Domains (4) summary

smart00220
Location:372 → 645

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:954 → 1031

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:371 → 650

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:63 → 336

DUF1908; Domain of unknown function (DUF1908)