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    Lclat1 lysocardiolipin acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lclat1provided by RGD
    Official Full Name
    lysocardiolipin acyltransferase 1provided by RGD
    Primary source
    RGD:1565906
    See related
    EnsemblRapid:ENSRNOG00000034026 AllianceGenome:RGD:1565906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lycat; RGD1565906
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.5), Lung (RPKM 24.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lclat1 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (27980749..28125076, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (22228933..22373246, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (24377398..24515412)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479330 Neighboring gene uncharacterized LOC102547438 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC100912066 Neighboring gene uncharacterized LOC108351184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome. Taylor WA, et al. Proc West Pharmacol Soc, 2007. PMID 18605246
    2. Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis. Danos M, et al. Biochem Cell Biol, 2008 Feb. PMID 18364741
    3. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. Zhao Y, et al. J Lipid Res, 2009 May. PMID 19075029, Free PMC Article
    4. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. Agarwal AK, et al. Arch Biochem Biophys, 2006 May 15. PMID 16620771
    5. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. Cao J, et al. J Biol Chem, 2004 Jul 23. PMID 15152008

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that increased mitochondrial monolysocardiolipin acyltransferase activity, and elevated cardiolipin resynthesis, may be a protective mechanism against monolysocardiolipin-mediated apoptosis.
      Title: Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis.
    2. cardiac mitochondrial monolysocardiolipin acyltransferase activity declines during postnatal development in the rat and that in utero exposure to alcohol inhibits cardiac monolysocardiolipin acyltransferase
      Title: Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysocardiolipin acyltransferase 1
    XP_038969005.1
    XP_038969006.1
    XP_038969007.1
    XP_038969009.1
    XP_038969010.1
    XP_038969011.1
    XP_063118810.1
    XP_063118811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431929.1 → NP_001418858.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    2. NM_001431930.1 → NP_001418859.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    3. NM_001431931.1 → NP_001418860.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    4. NM_001431932.1 → NP_001418861.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    5. NM_001431933.1 → NP_001418862.1  lysocardiolipin acyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    6. NM_001431934.1 → NP_001418863.1  lysocardiolipin acyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFV0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      27980749..28125076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113081.2 → XP_038969009.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000112795.1, ENSRNOT00000160802.1
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 306
      Acyltransf_C; Acyltransferase C-terminus

    2. XM_039113082.2 → XP_038969010.1  lysocardiolipin acyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cd07990
      Location:55 → 209
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

    3. XM_039113078.2 → XP_038969006.1  lysocardiolipin acyltransferase 1 isoform X1

      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 306
      Acyltransf_C; Acyltransferase C-terminus

    4. XM_039113079.2 → XP_038969007.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000112548.1, ENSRNOT00000166282.1
      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 306
      Acyltransf_C; Acyltransferase C-terminus

    5. XM_063262741.1 → XP_063118811.1  lysocardiolipin acyltransferase 1 isoform X1

      Related
      ENSRNOP00000050960.3, ENSRNOT00000043641.7

    6. XM_063262740.1 → XP_063118810.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFV0, A6HA05, D3ZFF4

    7. XM_039113083.2 → XP_038969011.1  lysocardiolipin acyltransferase 1 isoform X3

      Conserved Domains (2) summary
      cd07990
      Location:1 → 188
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:173 → 246
      Acyltransf_C; Acyltransferase C-terminus

    8. XM_039113077.2 → XP_038969005.1  lysocardiolipin acyltransferase 1 isoform X1

      Conserved Domains (2) summary
      cd07990
      Location:55 → 248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:233 → 306
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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