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    Ddx49 DEAD-box helicase 49 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddx49provided by RGD
    Official Full Name
    DEAD-box helicase 49provided by RGD
    Primary source
    RGD:1311124
    See related
    EnsemblRapid:ENSRNOG00000022368 AllianceGenome:RGD:1311124
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 96.2), Adrenal (RPKM 96.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx49 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19159353..19167003)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19125388..19133042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20873585..20881312)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene COPI coat complex subunit epsilon Neighboring gene homer scaffold protein 3 Neighboring gene SURP and G patch domain containing 2 Neighboring gene transmembrane protein 60-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA. Awasthi S, et al. Nucleic Acids Res, 2018 Jul 6. PMID 29618122, Free PMC Article
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of rRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX49
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
    NP_001108495.1
    XP_063131257.1
    XP_063131258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115023.1 → NP_001108495.1  probable ATP-dependent RNA helicase DDX49

      See identical proteins and their annotated locations for NP_001108495.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158855
      UniProtKB/TrEMBL
      A0A8I6A3R8, B0BNK0
      Related
      ENSRNOP00000004891.5, ENSRNOT00000004891.8
      Conserved Domains (4) summary
      PTZ00424
      Location:4 → 382
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:218 → 351
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:4 → 206
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cl19511
      Location:363 → 454
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19159353..19167003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275187.1 → XP_063131257.1  probable ATP-dependent RNA helicase DDX49 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3R8, E9PTF0

    2. XM_063275188.1 → XP_063131258.1  probable ATP-dependent RNA helicase DDX49 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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