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    Zfp219 zinc finger protein 219 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp219provided by RGD
    Official Full Name
    zinc finger protein 219provided by RGD
    Primary source
    RGD:1359259
    See related
    EnsemblRapid:ENSRNOG00000011544 AllianceGenome:RGD:1359259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf219
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in limb bud formation; positive regulation of chondrocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF219 (zinc finger protein 219). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 83.5), Lung (RPKM 59.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp219 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27169335..27183555, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24695831..24710039, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28402412..28417379, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribonuclease A family member 13 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 7 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene transmembrane protein 253 Neighboring gene ribosomal protein L31 like 10 Neighboring gene olfactory receptor family 5 subfamily AU member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. Sakai T, et al. DNA Res, 2000 Apr 28. PMID 10819330
    2. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. Sakai T, et al. DNA Res, 2003 Aug 31. PMID 14621294
    3. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. Clough RL, et al. J Neurochem, 2009 Sep. PMID 19549071
    4. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. Takigawa Y, et al. J Cell Sci, 2010 Nov 1. PMID 20940257
    5. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94294

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in limb bud formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 219

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007681.1 → NP_001007682.1  zinc finger protein 219

      See identical proteins and their annotated locations for NP_001007682.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082017
      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27169335..27183555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251880.5 → XP_006251942.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006251942.1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_063274223.1 → XP_063130293.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Related
      ENSRNOP00000080079.1, ENSRNOT00000097305.2

    3. XM_063274224.1 → XP_063130294.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48

    4. XM_017599667.3 → XP_017455156.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_039093274.2 → XP_038949202.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_039093277.2 → XP_038949205.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    7. XM_039093276.2 → XP_038949204.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_039093275.2 → XP_038949203.1  zinc finger protein 219 isoform X1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    9. XM_006251878.5 → XP_006251940.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006251940.1

      UniProtKB/TrEMBL
      A6KEF7, A6KEF8, F7F3U8, Q66H48
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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