Hmgn5 high mobility group nucleosome binding domain 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hmgn5provided by RGD
Official Full Name: high mobility group nucleosome binding domain 5provided by RGD
Primary source: RGD:6497694
See related: EnsemblRapid:ENSRNOG00000029078 AllianceGenome:RGD:6497694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nsbp1
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of cell population proliferation; and positive regulation of gene expression. Predicted to act upstream of or within chromatin organization; glutathione metabolic process; and regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human HMGN5 (high mobility group nucleosome binding domain 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 17.3), Testes (RPKM 16.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (78161439..78170613, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (74085871..74094488, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (80134557..80142902, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high mobility group nucleosome-binding domain-containing protein 5

Names: nucleosome-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276434.1 → NP_001263363.1 high mobility group nucleosome-binding domain-containing protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZU29

Related

ENSRNOP00000064623.3, ENSRNOT00000071650.4

Conserved Domains (1) summary

pfam01101
Location:2 → 93

HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

78161439..78170613 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099388.2 → XP_038955316.1 high mobility group nucleosome-binding domain-containing protein 5 isoform X1

UniProtKB/Swiss-Prot

B4F777

UniProtKB/TrEMBL

A6IV78

Related

ENSRNOP00000047671.6, ENSRNOT00000048744.7

Conserved Domains (2) summary

TIGR00927
Location:218 → 423

2A1904; K+-dependent Na+/Ca+ exchanger

pfam01101
Location:1 → 95

HMG14_17; HMG14 and HMG17