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    Arvcf ARVCF, delta catenin family member [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arvcfprovided by RGD
    Official Full Name
    ARVCF, delta catenin family memberprovided by RGD
    Primary source
    RGD:1306655
    See related
    EnsemblRapid:ENSRNOG00000001888 AllianceGenome:RGD:1306655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity. Predicted to be involved in RNA splicing and cell-cell adhesion. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in DiGeorge syndrome. Orthologous to human ARVCF (ARVCF delta catenin family member). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 48.8), Lung (RPKM 37.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arvcf in Genome Data Viewer
    Location:
    11q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96092451..96150144, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82588137..82645832, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86736125..86793795, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 1 like Neighboring gene uncharacterized LOC120095703 Neighboring gene thioredoxin reductase 2 Neighboring gene catechol-O-methyltransferase Neighboring gene small Cajal body-specific RNA 14 like 2 Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185 Neighboring gene AP-3 complex subunit sigma-1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Kausalya PJ, et al. Mol Biol Cell, 2004 Dec. PMID 15456900, Free PMC Article
    2. Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Sirotkin H, et al. Genomics, 1997 Apr 1. PMID 9126485
    3. mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing. Waibler Z, et al. J Cell Sci, 2001 Nov. PMID 11719554
    4. The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. Kaufmann U, et al. J Cell Sci, 2000 Nov. PMID 11058098
    5. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. Laura RP, et al. J Biol Chem, 2002 Apr 12. PMID 11821434

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC188400

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing regulator ARVCF
    Names
    armadillo repeat gene deleted in velo-cardio-facial syndrome
    armadillo repeat protein deleted in velo-cardio-facial syndrome
    armadillo repeat protein deleted in velo-cardio-facial syndrome homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131013.2 → NP_001124485.1  splicing regulator ARVCF

      See identical proteins and their annotated locations for NP_001124485.1

      Status: VALIDATED

      Source sequence(s)
      BC168253, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      B4F7F3
      UniProtKB/TrEMBL
      F7FK74
      Related
      ENSRNOP00000047113.5, ENSRNOT00000044635.7
      Conserved Domains (3) summary
      cd00020
      Location:356 → 474
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:361 → 463
      HEAT_2; HEAT repeats
      sd00043
      Location:361 → 386
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96092451..96150144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F7F3.1 GenPept UniProtKB/Swiss-Prot:B4F7F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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